Varun Jayeshkumar Shah

NEWS AND VIEWS 15 July 2026 Some nucleotides have been shown to control metabolism by ‘gluing’ proteins together. Could other small molecules made naturally by cells have similar capabilities? Access to this article via EBSCO Subscription Services PO Box 1943 is not available. Some of the most exciting therapies to have emerged in the past decade are what are known as proximity-inducing drugs.

Keywords molecular glues cereblon targeted protein degradation IMiDs PROTACs degraders ubiquitin Introduction Targeted protein degradation (TPD) has emerged as an important therapeutic modality that utilizes bifunctional degrader molecules, such as proteolysis targeting chimeras (PROTACs) or molecular glues (MGs), to recognize and recruit specific proteins to E3 ligase complexes for ubiquitination and subsequent degradation via the cellular ubiquitin-proteasome system.1,2,3 The majority of...

In the ever-evolving landscape of technology, Artificial Intelligence (AI) and Machine Learning (ML) have emerged as revolutionary forces, reshaping the traditional paradigms of software development. The integration of these cutting-edge technologies has ushered in a new era, where efficiency, innovation, and user-centricity take center stage. AI and ML in Software Development 1.