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Feeding Behaviour in the KPC Model of Pancreatic Cancer-Associated Cachexia: Alteration of Spontaneous and Evoked Feeding Behaviours
1 Introduction Feeding is organized into discrete bouts (meals) that collectively determine total food intake. The dimensions of meals—their size, feeding rate, duration and interval—are regulated by neuronal circuits informed by feedback related to nutrient inflow that shape the progression of ingestion.
Harnessing lipid-driven immunometabolic pathways in omental metastases to enhance immunotherapy in patients with ovarian cancer - Signal Transduction and Targeted Therapy
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Abstract Immunotherapy with immune checkpoint blockade (ICB) in epithelial ovarian carcinoma (EOC) shows limited clinical benefit only for a small subset of patients. Overall response rates are low, so that overcoming immunotherapy resistance and improved stratification are key.
By Meggy Suarez-Carmona, Mareike Hampel, Xin-Wen Zhang, Nektarios A. Valous, Pornpimol Charoentong, Dyke Ferber, Jannis Wissfeld, Stanislas Goriely, Abdulkader Azouz, Anthony Rongvaux, Sven Zukunft, Ingrid Fleming, Jürgen G. Okun, Vickie E. Baracos, Mathias Heikenwalder, Laurence Zitvogel, Xinyi Xu, Chenqi Xu, Michael Volkmar, Daniel Schraivogel, Lars M. Steinmetz, Junzo Hamanishi, Masaki Mandai, Matthias Martin Gaida, Theresa Mokry, Johanna Nattenmüller, Oliver Sedlaczek, Nanna Monjé, Roxana Schwab, Annette Hasenburg, Athanasios Mavratzas, Frederik Marmé, Sarah Schott, Niels Halama, Alexandra Pöchmann, Silke A. Grauling-Halama, Alicia Höflich, Aurélie Detavernier, Regina Johanna Boger
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Nature
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Pathways Contributing to Chemotherapy‐Induced Myotoxicity Are Attenuated by EPA + DHA in a Clinically Relevant Model of Colorectal Cancer
1 Introduction It is increasingly recognized that drugs used to treat tumours also exert deleterious effects on muscle [1]. Myotoxicity is now considered to be one of the negative effects of systemic treatments impairing muscle function, compromising treatment response and escalating toxicities [2].
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