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Vigneshwaran Vellingiri on Muck Rack

Vigneshwaran Vellingiri

As seen in: BioRxiv, The Journal of Clinical Investigation
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Articles

ERG-lacking endothelium identifies IL8-CXCR2 axis as a therapeutic target for resolving neutrophilic lung vascular injury

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By JCI Insight, Vigneshwaran Vellingiri, Jagdish Joshi
| The Journal of Clinical Investigation
ResearchInflammationPulmonologyVascular biology Open Access | 10.1172/jci.insight.195989 JCI Insight. https://doi.org/10.1172/jci.insight.195989. Copyright © 2026, Vellingiri et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. View PDF Abstract Aberrant neutrophil (PMN) accumulation in the tissue induces chronic vascular diseases.
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A Single Mutation in TRPC6 Protects Mice from Acute Lung Injury by Regenerating Endothelium

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By Mumtaz Anwar, Ruhul Amin, Vigneshwaran Vellingiri, Jagdish Joshi
| BioRxiv
Abstract Regenerating vascular endothelium under sepsis, trauma, and viral infections is vital for promoting the resolution of inflammatory diseases such as acute lung injury (ALI). Transient receptor potential canonical (TRPC) channels mediated Ca2+ entry compromises organ functions and survival from lung injury. Through decoding the domain in TRPC6 responsible for vascular injury, we unveiled the intricate molecular mechanisms underlying vascular regeneration in injured tissue.
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Endothelial ERG programs neutrophil transcriptome for sustained anti-inflammatory vascular niche

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By Vigneshwaran Vellingiri, Vijay Avin BR, Jagdish Joshi, Zahid Akhter
| BioRxiv
Abstract Neutrophils (PMNs) reside as a marginated pool within the vasculature, ready for deployment during infection. However, how endothelial cells (ECs) control PMN extravasation and activation to strengthen tissue homeostasis remains ill -defined. Here, we found that the vascular ETS-related gene (ERG) is a generalized mechanism regulating PMN activity in preclinical tissue injury models and human patients.
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