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KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

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By Ana Galan-Cobo, Natalie I. Vokes, Yu Qian, David P Molkentine, Kavya Ramkumar, Alvaro G. Paula, Marlese Pisegna, Daniel J. McGrail, Alissa Poteete, Sungnam Cho, Minh Truong Do, Amirali Karimi, Yifan Kong, Anisha Solanki, Ankur Karmokar, Nicolas Floc’h, Adina M. Hughes, Rebecca Sargeant Verified, Lucy Young, Li Shen, Gozde Kar, Caezaan Keshvani, Claudio Arrechedera, Sharia Hernandez, Katharina Schlacher, Jing Wang, Sonia Iyer, James Conway, Mohamed Reda Keddar, Marta Milo, Ilario De Toma, Susan Critchlow, J. Carl Barrett, Jan Cosaert, Alan Lau Verified, Viia Valge-Archer, Lauren A Byers, Simon T. Barry, John Heymach
| Cell Press Verified
Keywords lung cancer NSCLC STK11 LKB1 KEAP1 DDR ATR inhibition ceralasertib immunotherapy Introduction KEAP1 is the third most commonly mutated tumor suppressor in lung adenocarcinoma (LUAD), and alterations in this gene commonly co-occur with KRAS activating mutations,1 the most prevalent oncogenic driver event in LUAD.2 KEAP1 is a negative regulator of NRF2, a master transcription factor that regulates anti-oxidative stress response.3 Thus, inactivating mutations in KEAP1 or activating...
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