Vincent Wu on Muck Rack

Vincent Wu

United States
As seen in: HuffPost, Nature, Wiley Online Library, ScienceDirect, MDPI, PNAS, ACS Publications, JAMA (The Journal of the American Medical Association), HuffPost UK, Science Magazine and
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Articles

The SCD inhibitor MTI-301 reduces steatohepatitis and ratio of C18:1/C18:0 levels in diet-induced murine models of MASH

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By Santhosh Shanthi Bhupathi, Karen Hayes, Kusum Sharma, Mark Eminhizer, Vincent Wu, Jianhai Du, Devanand Sarkar, Sijin Wen, John Maringa Githaka, Werner J Geldenhuys, Lori Hazlehurst, Sridhar Reddy Kaulagari, John A. Copland III
| Nature
Abstract Metabolic dysfunction-associated steatohepatitis (MASH) and metabolic dysfunction-associated steatotic liver disease (MASLD) develop because of fat disposition and excess accumulation of lipid droplets in hepatocytes and hepatic stellate cells. The endoplasmic reticulum enzyme stearoyl-CoA desaturase (SCD) is the rate-limiting enzyme that converts saturated fatty acids (SFAs) to monounsaturated fatty acids (MUFAs).
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In vivo reprogramming of cytotoxic effector CD8 T cells via fractalkine-conjugated mRNA-LNPs

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By Juan Villar-Vesga, Angela Corrigan, Shin Foong Ngiow, Maura Statzu, M. Betina Pampena, Stephen D Carro, Justin Harper, Rachelle Stammen, Jennifer Wood, Houping Ni, Justin M. Su, Marziyeh Hajialyani, Vladimir V. Shuvaev, Jacob Hamilton, Vincent Wu, Mirko Paiardini, Drew Weissman, E. John Wherry, Edward F. Kreider, Michael Betts, Amie Albertus, Jayme M. L. Nordin, Victor Alcalde, Mohammed-Alkhatim A. Ali, Rajesvaran Ramalingam
| Science Magazine
Editor’s summary Adoptive cell therapies have been engineered to treat various cancers or autoimmune diseases, but methods have been limited in their ability to target cytotoxic effector CD8 T (Teff) cell subsets in vivo. Corrigan et al. used fractalkine-conjugated mRNA lipid nanoparticles (mRNA-LNPs) to deliver mRNA to CX3CR1+ Teff cells in vivo. Fractalkine is also known as CX3CL1 and binds specifically to its receptor CX3CR1.
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KACTUS Publishes Framework for 2+1 and Trispecific TCE Scaffold Design

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By Vincent Wu
| Virgin Islands Business Journal
WALTHAM, MA, April 23, 2026 (GLOBE NEWSWIRE) -- WALTHAM, MA - April 23, 2026 - - KACTUS has published a technical framework for engineering 2+1 and trispecific T-cell engager therapeutics, addressing structural scaffold challenges for drug discovery teams advancing beyond conventional bispecific formats. KACTUS, a leading recombinant protein manufacturer, has published a technical framework for engineering 2+1 and trispecific T-cell engager (TCE) therapeutics.
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