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Viola Denninger on Muck Rack

Viola Denninger

As seen in: Nature, Cell Press
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Articles

T cell immunomonitoring: a comparative analysis of traditional and novel methods to quantify and characterize human antigen-specific T cells

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By Geert Leroux-Roels, Bruno Salaün Verified, Laura Cook, Katka Franke, Isabel Poschke, Lukas Bunse, Michael G. Fehlings, Sofie Pattyn, Liselotte Brix, Noah J. Tubo, Jeffrey J. Molldrem, Viola Denninger, Nikolaj Pagh Kristensen, Yolanda D. Mahnke, Florian Mair, Kilian Schober, Sven Koch, Sandra Lazzaro, Sylvia Janetzki, Marij J. P. Welters, Gwenn Waerlop, Wim J. E. van Esch
| Nature Verified
Abstract T cells are a key component of the adaptive immune system, playing a central role in the body’s defense against pathogens and diseases. Antigen discovery and longitudinal immunomonitoring of antigen-specific T cell responses offer valuable insights into the activity and efficacy of immunotherapies and can guide development of new prophylactic or therapeutic treatments, such as vaccines and cellular therapies.
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Aurora B-INCENP Localization at Centromeres/Inner Kinetochores Is Required for Chromosome Bi-orientation in Budding Yeast

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By Tomoyuki Tanaka, Luis J. García-Rodríguez, Taciana Kasciukovic, Viola Denninger
| Cell Press Verified
Highlights • The COMA inner kinetochore sub-complex facilitates chromosome bi-orientation • COMA physically interacts with Sli15 and recruits Ipl1-Sli15 to the inner kinetochore • This function of COMA is independent of Bir1 and its role supporting robust cohesion • Localizing Ipl1-Sli15 at centromeres/inner kinetochores is crucial for bi-orientation Summary For proper chromosome segregation in mitosis, sister kinetochores must interact with microtubules from opposite spindle poles...
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