Wangsen Cao

Abstract Mycobacterium tuberculosis (M.tb) actively reprograms host lipid metabolism during infection; however, the underlying mechanism remains poorly understood. How M.tb manipulates macrophage lipid metabolism to induce lipid peroxidation and ferroptosis for bacterial persistence remains a fundamental question. Here, using single-cell RNA sequencing and proteomics, we show that M.tb infection substantially upregulates peroxisome proliferator-activated receptor gamma (PPARγ) in macrophages.

Keywords cancer cachexia muscle atrophy methionine metabolism DNMT DNA methylation C2C12 myotubes epigenetic regulation ER stress REDD1 Get full text access Log in, subscribe or purchase for full access. References 1. Baracos, V.E. ∙ Martin, L. ∙ Korc, M. ... Cancer-associated cachexia Nat. Rev. Dis. Primers. 2018; 4, 17105 2. Argilés, J.M. ∙ López-Soriano, F.J. ∙ Stemmler, B. ... Cancer-associated cachexia - understanding the tumour macroenvironment and microenvironment to improve management Nat. Rev. Clin.

Abstract Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferation of keratinocytes and persistent inflammation. Although persistent activation of signal transducer and activator of transcription 3 (STAT3) is implicated in its pathogenesis, the mechanisms underlying the sustained STAT3 activation remain poorly understood.