Yingwei Zhang
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Computer Science > Artificial Intelligence
IMU-based human activity recognition (HAR) enables continuous, privacy-friendly monitoring of daily activities using wearable sensors. However, building reliable HAR models that generalize across diverse users and real-world conditions requires large amounts of labeled IMU data, which are expensive and difficult to collect.
Mycobacterium tuberculosis IDH-PPARγ interaction suppresses GPX4 to drive macrophage ferroptosis and sustain persistent infection
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Abstract Mycobacterium tuberculosis (M.tb) actively reprograms host lipid metabolism during infection; however, the underlying mechanism remains poorly understood. How M.tb manipulates macrophage lipid metabolism to induce lipid peroxidation and ferroptosis for bacterial persistence remains a fundamental question. Here, using single-cell RNA sequencing and proteomics, we show that M.tb infection substantially upregulates peroxisome proliferator-activated receptor gamma (PPARγ) in macrophages.
By Wenyuan Pu, XiMeng Zhang, Man Tian, Zhiyi He, Jin Zhu, Shiyu Song, Panpan Lian, Renwei Lu, Ranran Wang, Kai Lin, Chaode Gu, Junaid Wazir, Caiyun Wang, Yixuan Sun, Jing Yang, Yingwei Zhang, Huimei Chen, Enrico Petretto, Wangsen Cao, Rongrong Fan, Eckardt Treuter, Xia Zhang, Nannan Liu, Airong Yang, Xinchun Chen, Hongwei Wang, Zhiqiang Huang
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Nature
Verified
Pathology and Transcriptomic Characteristics of Skin Lesions Induced by Mpox Virus in Rabbit
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1 and , “Monkeypox Virus,” Bacteriological Reviews 37, no. 1 (1973): 1–18. 2, , , et al., “Human Monkeypox,” Bulletin of the World Health Organization 46, no. 5 (1972): 569–576.
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