Warsha Barde

Abstract Humans select and learn goal-directed actions through the anticipation of their outcomes. While this ideomotor principle is well established in humans, its biological instantiation and relevance for organizing naturalistic behavior remain unclear, including its neurobiological substrates such as hippocampal plasticity.

Keywords hippocampus plasticity learning stem cells neural networks Introduction Adult neurogenesis has always been good for discussions. After its original description by Joseph Altman and Gopal Das in 1965,1 it remained an intriguing curiosity for decades that inspired speculation but never entered mainstream neurobiological concepts.

Abstract Alzheimer’s disease has a long preclinical phase, during which no overt signs of the manifest disease are present, but subtle, usually non-specific changes are already detectable. Emerging early biomarkers underscore the importance of this phase for preventive measures including lifestyle interventions. As a reductionistic model for lifestyle factors, we used a novel enrichment paradigm in which AppNL-G-F knock-in mice were continuously tracked until 7 months of age.