By Sara Erickson, PharmD, BCACP; Anna Bartoo, PharmD, BCPS; Amy Wallingford, PharmD; Susan Wescott, MBA, RPh; Chelsee Jensen, PharmD, BCPS, P-RCM, RPh Biosimilars offer a significant opportunity for cost-savings yet present logistical hurdles for optimal implementation. Biosimilar savings nationwide are estimated to be $54 billion from 2017 to 2026, but these savings hinge on industry, regulatory, and policy changes to strengthen competition and sustainability in the biosimilar marketplace.