Weina Shang

Keywords mitochondria OXPHOS respiration complex mitochondrial protease Drosophila Get full text access Log in, subscribe or purchase for full access. References 1. Nunnari, J. ∙ Suomalainen, A. Mitochondria: in sickness and in health Cell. 2012; 148:1145-1159 2. Pahal, S. ∙ Mainali, N. ∙ Balasubramaniam, M. ... Mitochondria in aging and age-associated diseases Mitochondrion. 2025; 82, 102022 3. Budinger, G.R.S. ∙ Chandel, N.S. Mitochondria dysfunction: cause or consequence of physiologic aging? Genes Dev.

Keywords mitochondria Drosophila HIBCH ECHS1 lysine methacrylation neurodegeneration Leigh syndrome Research topic(s) CP: Molecular biology CP: Neuroscience Introduction Leigh syndrome is a progressive neurodegenerative disease that affects 1 in 40,000 live births and is usually present in infancy or early childhood.1 There is still no cure or effective interventional therapy available for patients.2 In the majority of patients, dysfunction of the respiratory chain (particularly complexes I,...

Abstract Endoplasmic reticulum (ER)–mitochondria contact sites (ERMCSs) are crucial for multiple cellular processes such as calcium signaling, lipid transport, and mitochondrial dynamics. However, the molecular organization, functions, regulation of ERMCS, and the physiological roles of altered ERMCSs are not fully understood in higher eukaryotes. We found that Miga, a mitochondrion located protein, markedly increases ERMCSs and causes severe neurodegeneration upon overexpression in fly eyes.