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Wen-Hsien Hou on Muck Rack

Wen-Hsien Hou

As seen in: British Journal of Cancer, Nature, Wiley Online Library, BioRxiv, Cell Press, Cell Reports, eLife
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Articles

Dysfunction of cortical GABAergic projection neurons as a major hallmark in a model of neuropsychiatric syndrome

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By Andrea Asenjo-Martinez, Katarina Dragicevic, Wen-Hsien Hou, Attila Ozsvar, Nikolaj Winther Hansen, Ulrich Pfisterer, Rasmus Rydbirk, Samuel Demharter, Bente Møller, Janina Gasthaus, Irina Korshunova, Jean-François Perrier, Marco Capogna, Navneet A. Vasistha, Konstantin Khodosevich
| Cell Press Verified
Keywords neuropsychiatric risk factors cortex GABAergic projection neurons somatostatin chemogenetics single-cell transcriptomics copy number variation schizophrenia maturation sleep Get full text access Log in, subscribe or purchase for full access. References 1. Cross-Disorder Group of the Psychiatric Genomics Consortium.
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Inhibitory fear memory engram in the mouse central lateral amygdala

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By Wen-Hsien Hou, Meet Jariwala, Kai-Yi Wang, Anna Seewald, Yu-Ling Lin, Alessia Ricci, Francesco Ferraguti, Cheng-Chang Lien, Marco Capogna, Yi-Chen Liou
| Cell Reports Verified
Highlights • Auditory fear conditioning triggers inhibitory synaptic plasticity in CeL neurons • An inhibitory engram, mainly composed of SST(+) neurons, is identified in the CeL • CeL inhibitory engrams participate in the encoding specificity of conditioned fear • Inhibiting CeL engrams enhances fear expression Summary Engrams, which are cellular substrates of memory traces, have been identified in various brain areas, including the amygdala.
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Non-Hebbian plasticity transforms transient experiences into lasting memories

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By Islam Faress, Valentina Khalil, Wen-Hsien Hou, Andrea Moreno
| eLife
eLife assessment This study presents important novel findings on how heterosynaptic plasticity can transform a weak associative memory into a stronger one, or produce a memory when stimuli were not paired. This work expands our views on the role of temporal- and input-specific plasticity in shaping learning and memory processes. The evidence, based on state-of-the-art in vivo manipulations, activity recordings, and behavioral analysis, is convincing.
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