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Single-cell analysis of the epigenome and 3D chromatin architecture in the human retina
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Most genetic risk variants linked to ocular diseases are nonprotein coding and presumably contribute to disease through dysregulation of gene expression; however, understanding their mechanisms has been impeded by incomplete annotation of transcriptional regulatory elements across...
Dose-dependent sensitivity of human three-dimensional chromatin to a heart disease–linked transcription factor
Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Structured Abstract INTRODUCTION Haploinsufficient mutations of transcription factors (TFs) resulting in reduced gene dosage are an underlying cause of human genetic developmental disorders affecting diverse tissue and cell types.
Epigenetic and 3D genome reprogramming during the aging of the human hippocampus
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Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Structured Abstract INTRODUCTION Aging is the strongest risk factor for neurodegenerative disease and is accompanied by memory decline and chronic inflammation in the brain. The hippocampus, a region essential for learning and memory, is particularly vulnerable to aging.
By Nathan R. Zemke, Zoë Grant, Yubao Cheng, Seoyeon Lee, Sainath Mamde, Nicole Berchtold, Hannah Indralingam, Pik Ki Lau, Keyi Dong, Emily Hsu, Amanda Yang, Chumo Chen, Qiurui Zeng, Varun Ajith, Liqi Tong, Daofeng Li, Ting Wang, Jingtian Zhou, Joseph R. Ecker, Christopher K. Glass, Carl Cotman, B. Maximiliano Garduño, Weronika M. Bartosik, Yasmine Tani, Chanrung Seng
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