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Wesley Lu

As seen in: Nature, Cell Press
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Articles by Wesley Lu

Personalized neoantigen-targeting cancer vaccines in ovarian cancer: a phase 1 trial

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By MacLean Sellars, Jessica Frank, Bohoon Shim, Allison Vanasse, Ruolin Liu, Cleo Forman, Chloe R. Tu, Su-Chun Cheng, Catherine Song, Kan Xiong, Haley E. Sax, Vipheaviny Chea, Wesley Lu, Micah Rickles-Young, Amit Sud, Martin Hayes, Oriol Olivé, Haley Greenslade, Carrie L. Cibulskis, Nir Hacohen, Edward F. Fritsch, Shuqiang Li, Kenneth J. Livak, Nabihah Tayob, Elizabeth Stover, Carolyn Krasner, Rebecca Porter, Ursula Matulonis, Gad Getz, Giacomo Oliveira, Patrick A. Ott, Jeremy Simon, Viktor A. Adalsteinsson, Derin B. Keskin, Panagiotis A. Konstantinopoulos, Catherine J. Wu, Kyohei K. Tabata, Antonia Kowelewski, Pia Jain, Andjela Crnjac, Savni Sarolkar
| Nature Verified
Abstract Personalized neoantigen-targeting cancer vaccines in the adjuvant setting are of increasing interest across malignancies. Here we report the results of a phase 1 clinical trial testing the feasibility and safety of personalized neoantigen-targeting cancer vaccines for high-grade epithelial ovarian cancer.
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Single-nucleus multimodal spatial transcriptomics reveals spatial colocalization of neoantigen-expressing tumor cells and cognate T cells

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By Adi Nagler, Amit Sud, Jack Ghannam, Lucas Pomerance, Camila Robles-Oteiza, Alexander B. Afeyan, Jackson A. Weir, Andrew Russell, Wesley Lu, McKayla Van Orden, Giovanni J. Marrero, Qiyu Gong, vipin kumar, Kun Huang, Chloe R. Tu, Emma Lin, Bohoon Shim, Gabriel De Oliveira, MacLean Sellars, Charles H. Yoon, David A Reardon, Toni K. Choueiri, Lars R. Olsen, Sabina Signoretti, Patrick A. Ott, David Braun, Giacomo Oliveira, Shuqiang Li, Kenneth J. Livak, Nir Hacohen, fei chen, Catherine J. Wu, Andrea Sonnenholzner
| Nature Verified
Abstract Improved methods to identify therapeutically relevant tumor neoantigens and their cognate T cells would aid the development of precision medicines for cancer. Here, we developed Slide-GoTags, a droplet-based single-nucleus spatial transcriptomics approach that characterizes neoantigen-specific immunity by integrating targeted transcript genotyping and T cell receptor (TCR) sequencing with single-nucleus RNA sequencing from the same slice of frozen tissue.
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