William Austin Nickols

Keywords translation activity mitoribosome mitochondria metabolism aging Introduction Organisms demonstrate remarkable adaptability to environmental stimuli by modulating gene expression to thrive under changing conditions. For instance, cells fine-tune mitochondrial biogenesis and function to adjust energy production pathways based on available carbon sources.

Abstract Longitudinal pathogen genotyping data from individual hosts can uncover strain-specific infection dynamics and their relationships to disease and intervention, especially in the malaria field.

Abstract Non-human-associated microbial communities play important biological roles, but they remain less understood than human-associated communities. Here, we assess the impact of key environmental sample properties on a variety of state-of-the-art metagenomic analysis methods. In simulated datasets, all methods performed similarly at high taxonomic ranks, but newer marker-based methods incorporating metagenomic assembled genomes outperformed others at lower taxonomic levels.