William B. Rosencrans

Abstract Chromatin compaction and internal motion are fundamental aspects of gene expression regulation. Here, we have investigated chromatin fibers comprising recombinant histone octamers reconstituted with double-stranded bacteriophage T4-DNA. The size of the fibers approaches the typical size of genomic topologically associated domains. Atomic force and fluorescence (correlation) microscopy have been used to assess the structural organization, histone-induced compaction, and internal motion.

He was born Feb. 25, 1946, in Sunbury, a son of the late Boyd Brosious and Laura Rosencrans. He worked as a road construction operator during his career employed largely by Clair C. Hauck. He is survived by three daughters and sons-in-law, Michelle F. and George Sadler, of Washington, Pa., Tina M. and Andrew Rains, of Northumberland, and Serene J. and Matthew Hirst, of Haslet, Texas; one son, William B. Rosencrans, of Washington, Pa.; 13 grandchildren; 20 great-grandchildren; his fiancé, Gail E.