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Articles by William Keyes
Senescent cells maintain viability through adhesion-dependent fragmentation that promotes debris deposition
ArticleOnline nowOpen access Affiliations & Notes 1Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Équipe Labellisée Ligue Contre le Cancer, Illkirch, France 2UMR7104, Centre National de la Recherche Scientifique (CNRS), Illkirch, France 3U1258, Institut National de la Santé et de la Recherche Médicale (INSERM), Illkirch, France 4Université de Strasbourg, Illkirch, France 5Department of Medical Oncology and Pneumology (Internal Medicine VIII), University Hospital...
Prevailing views of cell senescence overlook its biological complexity
Although cell senescence is framed mainly as a stress response that promotes ageing, it is also programmed and evolutionary conserved and contributes to embryonic development and physiology. These latter points are frequently not known or are ignored. We emphasize that its conceptualization needs to include such roles, and that this complexity should guide future research.
The End
This is a rap I did two years ago.
My Climate Change Playlist
My Climate Change Playlist I am a music composer and I have composed 16 songs related to climate change. You can click on the following link to listen to them if you like. https://on.soundcloud.com/VfZjCxTHK2g3mz8M6
The Killing of Hind Rajab In Gaza
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It's Too Late
Here is a rap I wrote 3 months ago. If you want to listen to it click on the link at the end.
Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria
Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria Danielle E. Mor, Salman Sohrabi, Rachel Kaletsky, William Keyes, Alp Tartici, Vrinda Kalia, Gary W. Miller, Coleen T. Murphy Proceedings of the National Academy of Sciences Oct 2020, 202009838; DOI: 10.1073/pnas.2009838117
CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling
Highlights • The transcription factor CREB regulates oocyte quality and reproductive decline • Hypodermal CREB downstream of TGF-β Sma/Mab signaling controls reproductive aging • CREB targets in the hypodermis include a Hedgehog-related signaling factor, wrt-10 • WRT-10 delays reproductive aging, potentially via germline Patched receptors Summary Evolutionarily conserved signaling pathways are crucial for adjusting growth, reproduction, and cell maintenance in response to altered...
An integrative tissue-network approach to identify and test human disease genes
Krishnan, A. et al. Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder . Nat. Neurosci. 19, 1454–1462 (2016). Rossin, E.J. et al. Proteins encoded in genomic regions associated with immune-mediated disease physically interact and suggest underlying biology . PLoS Genet. 7, e1001273 (2011). Pendse, J. et al.
Insulin Signaling Regulates Oocyte Quality Maintenance with Age via Cathepsin B Activity
We were struck by the fact that four of the 30 IIS oocyte-specific downregulated genes (Figures 1Figures 1C and 22A ; Data S1x Download (.07 MB ) Data S1.
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