William Pearson on Muck Rack

William Pearson

As seen in: Part-Time Genius, Emerging Infectious Diseases, Nature, PLOS ONE, SAGE Publishing, Sexually Transmitted Infections, Medscape, Stars and Stripes, Annals of Internal Medicine, American Journal of Public Health, Grand Island Independent and
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Articles

Targeting de novo purine biosynthesis for tuberculosis treatment - Nature Original

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By Dirk A. Lamprecht, Richard Wall, Stijn Daems, William Pearson, Ann Vos, Jorge Esquivias, Gerald Larrouy-Maumus, Bree B. Aldridge, Jansy P. Sarathy, Neeraj Dhar, Clara Aguilar-Pérez, Hope D’Erasmo, Ruxandra Draghia Akli
| Nature
Abstract Tuberculosis remains the leading cause of death from an infectious disease1,2. Here we report the discovery of a first-in-class small-molecule inhibitor targeting PurF, the first enzyme in the mycobacterial de novo purine biosynthesis pathway. The lead candidate, JNJ-6640, exhibited nanomolar bactericidal activity in vitro. Comprehensive genetic and biochemical approaches confirmed that JNJ-6640 was highly selective for mycobacterial PurF.
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Primary care screening for sexually transmitted infections in the United States from 2019 to 2021

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By Shiying Hao, Esther Velasquez, William Pearson
| PLOS ONE
We summarized baseline demographic characteristics for all patients and further stratified the demographic characteristics by specific STI testing during the study period. We performed Chi-Square tests to determine whether differences observed were likely due to chance. We applied the standardization to the monthly and annual rates of STI tests. Direct age adjustment was based on using the reference U.S. age distribution per the U.S. Census 2020 data for the study period.
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Treatment of Chlamydia and Gonorrhea in Primary Care and Its Patient-Level Variation: An American Family Cohort Study

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By Shiying Hao, Guoyu Tao, William Pearson, Ilia Rochlin
| Annals of Family Medicine
Research ArticleOriginal Research Treatment of Chlamydia and Gonorrhea in Primary Care and Its Patient-Level Variation: An American Family Cohort Study Shiying Hao, Guoyu Tao, William S. Pearson, Ilia Rochlin, Robert L. Phillips, David H. Rehkopf and Neil Kamdar Abstract PURPOSE Chlamydia and gonorrhea are the 2 most common bacterial sexually transmitted infections in the United States. Nonadherence to the Centers for Disease Control and Prevention treatment guidelines remains a concern.
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