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Wumei Blanche on Muck Rack

Wumei Blanche

As seen in: BioRxiv
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Articles

The complement regulator CD55 modulates TLR9 signaling and supports survival in marginal zone B cells

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By Iris Lee, SONAM VERMA, Ivana Ling, Wumei Blanche
| BioRxiv
Abstract Marginal zone (MZ) B cells bridge innate and adaptive immunity by sensing bloodborne antigens and producing rapid antibody and cytokine responses. CD55 is a membrane-bound complement regulator that interferes with complement activation, an important component of innate immunity. CD55 also regulates adaptive immunity-CD55 downregulation is critical for germinal center reactions. MZ B cells also express low CD55, but its role in MZ B cell function is unknown.
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