CONFLICT OF INTEREST The authors declare no conflicts of interest. DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description ps70575-sup-0001-Supinfo01.docWord document, 1.4 MB Figure S1. Detoxifying enzyme activity induced by isocycloseram LD10 in Plutella xylostella and Arma chinensis. (A) The activity of ESTs induced by isocycloseram LD10 in P. xylostella.