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Articles by Xia Ding
The cGAS–STING pathway in pulmonary infectious and sterile inflammation: differences, connections, and therapeutic implications
Abstract The cyclic GMP–AMP synthase–stimulator of interferon genes (cGAS–STING) signaling pathway plays a pivotal role in mediating both infectious and sterile pulmonary inflammation, exhibiting distinct dynamic characteristics under different contexts. The activation kinetics of the cGAS–STING pathway are highly dependent on disease context.
Correction: Electronic health literacy and related factors among nursing students: a latent profile analysis
A Correction on Electronic health literacy and related factors among nursing students: a latent profile analysis by Xu, L., Li, N., Ding, X., Wang, H., Yin, P., and Pan, W. (2026). Front. Public Health 14:1845664. doi: 10.3389/fpubh.2026.1845664 In the published article, there was an error in the affiliation order for all authors.
Electronic health literacy and related factors among nursing students: a latent profile analysis
Abstract Background: In the context of rapid information technology development and widespread internet-based healthcare, electronic health literacy (eHL) is essential for health promotion and disease prevention. As prospective nurses, nursing students require sufficient eHL to retrieve, evaluate, and apply digital health information in clinical practice and health education.
Genetic Evidence Implicating Gut Microbiota and Circulating Cytokines in Sjögren's Syndrome
1 Introduction Sjögren's syndrome (SS) is a complex autoimmune disorder characterized by immune system dysregulation that primarily targets the exocrine glands, particularly the salivary and lacrimal glands [1]. Its prevalence rates vary across different demographics, ranging from 0.04% to 0.6%, with a clear predilection for female individuals [2].
DNA Methylation‐Regulated ZDHHC17 Promotes the Risk of Facial Skin A
Back to Journals » Clinical, Cosmetic and Investigational Dermatology » Volume 18 Authors Cai X , Li W, Shi W, Ding X, Cai Y Received 22 August 2025 Accepted for publication 9 December 2025 Published 18 December 2025 Volume 2025:18 Pages 3471—3482 DOI https://doi.org/10.2147/CCID.S562516 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Monica K.
Development of a Nomogram for Prognostic Prediction of Large Hepatocellular Carcinoma With HBV After TACE Combined Conversion Therapy
Abstract Background Surgical resection (SR) following transarterial chemoembolization (TACE) is a promising option for large hepatocellular carcinoma (LHCC) with HBV, and identification of these patients at high-risk of prognosis may help individualized treatment. Purpose To develop and validate pre- and postoperative prognostic nomograms integrating clinico-therapeutic-pathological features for predicting overall survival (OS) after TACE combined therapy.
CHI3L1: a key driver in gastritis-to-cancer transformation - Journal of Translational Medicine
In Situ Crosslinked Biodegradable Hydrogels Based on Poly(Ethylene Glycol) and Poly(ε-Lysine) for Medical Application
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In Situ Crosslinked Biodegradable Hydrogels Based on Poly(Ethylene Glycol) and Poly(ε-Lysine) for Medical Application
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 15 October 2024 / Approved: 15 October 2024 / Online: 15 October 2024 (10:45:54 CEST) Ding, X.; Yang, B.; Hou, Z. In Situ Crosslinked Biodegradable Hydrogels Based on Poly(Ethylene Glycol) and Poly(ε-Lysine) for Medical Application. Preprints 2024, 2024101171. https://doi.org/10.20944/preprints202410.1171.v1 Ding, X.; Yang, B.; Hou, Z.
Natural Derivatives of Selective HDAC8 Inhibitors with Potent in Vivo Antitumor Efficacy against Breast Cancer
Abstract Click to copy section linkSection link copied! HDAC8 is a therapeutic target with great promise for breast cancer. Here, we reported a novel compound corallorazine D from Nocardiopsis sp. XZB108, selectively inhibited HDAC8 (IC50 = 0.90 ± 0.014 μM), suggesting that it may be a promising nonhydroxamate HDAC8 inhibitor.
Efficacy and safety of Weifuchun tablet for chronic atrophic gastritis: A systematic review and meta-analysis
Loading metrics Open Access Peer-reviewed Research Article Abstract Background Chronic atrophic gastritis is a significant premalignant lesion of gastric carcinoma. There is a great need to prevent the progression to gastric carcinoma through early intervention and treatment for chronic atrophic gastritis. Weifuchun, a famous Chinese patent drug, has been widely used for chronic atrophic gastritis in China. However, it remains unclear whether Weifuchun is effective for atrophic gastritis.
Hepatitis B surface antigen kinetics after discontinuation of and retreatment with oral antivirals in non‐cirrhotic HBeAg‐positive chronic hepatitis B
ORIGINAL ARTICLE Hongjie Chen Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou, China Search for more papers by this author Xia Ding Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, State Key Laboratory of Organ Failure Research, Guangdong Provincial Key Laboratory of Viral Hepatitis Research, Guangzhou,...
Degradation of 5hmC-marked stalled replication forks by APE1 causes genomic instability
TET2 and 5hmC mark the forks for APE1 Inhibitors of the enzyme PARP, commonly used to treat various tumors, block the repair and restart of stalled replication forks, which eventually kills cancer cells. Kharat et al. found that the DNA demethylase TET2—which is associated with epigenetic control of transcription—was critical for sensitivity to PARP inhibitors by promoting repair-mediated degradation of stalled forks.
TIMP-1 Mediates Inflammatory and Immune Response to IL-6 in Adult Orbital Xanthogranulomatous Disease
Purpose: To explore the pathogenesis that TIMP-1 mediated in adult orbital xanthogranulomatous disease (AOXGD), a rare type of non-Langerhans histiocytosis that damages the appearance and quality of life of patients Methods: We reviewed 22 patients diagnosed with AOXGD based on clinical manifestations and histological analysis, and then investigated the expression of TIMP-1 and IL-6 with q-PCR and IHC in AOXGD tissues and the possible mechanism involved in the induction of TIMP-1 by IL-6.
Controllable Propagation of Bending Waves in Wrinkled Films
Savin, T., Kurpios, N. A., Shyer, A. E., Florescu, P., Liang, H., Mahadevan, L., and Tabin, C. J., 2011, “On the Growth and Form of the Gut,” Nature, 476(7358), pp. 57–62. [CrossRef] [PubMed] Wong, Y. W., and Pellegrino, S., 2006, “Wrinkled Membranes Part I: Experiments,” J. Mech. Mater. Struct., 1(1), pp. 3–25. [CrossRef] Li, B., Cao, Y.-P., Feng, X.-Q., and Gao, H., 2012, “Mechanics of Morphological Instabilities and Surface Wrinkling in Soft Materials: A Review,” Soft Matter, 8(21), pp. 5728–5745.
Erratum: Replication fork stability confers chemoresistance in BRCA-deficient cells
Nature 535, 382–387 (2016); doi: 10.1038/nature18325It has come to our attention that in this Article, owing to an error during the production process, ‘Brca2’ was mislabelled as ‘Brca1’ in Fig. 4b, and ‘Parp1’ was mislabelled as ‘Ptip’ in Fig. 4e. These errors have been corrected in the online versions of the paper.
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies
PARPi are selectively toxic to HR-deficient cells4, 5. However, effects of PARPi are not limited to HR-deficient cells, as treatment of HR-proficient cells with different doses of olaparib resulted in suppression of CHK1 activation in response to replicative stress (Supplementary Fig. 1a), as reported previously19.
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