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Xiaozhi Lu

As seen in: Nature, Science Magazine, BioRxiv, Cell Press, Cell Reports
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Articles by Xiaozhi Lu

Mechanistic and antigenic boundaries of Henipavirus and Parahenipavirus glycoproteins

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By Aaron May, Muralikrishna Lella, Jared Lindenberger, Alex Berkman, Ujjwal Kumar, Kejun Liu, Moumita Dutta, Maggie Barr, Rob Parks Verified, Xiaozhi Lu, Madison Berry, Amanda Powell, Amelia Thompson, Sravya Sowdamini Nakka, Camila T. França, Xiao Huang, Arpita Mrigwani, Kijun Song, Salam Sammour, Chan Soo Park, Radha Adhikari, Katarzyna Janowska, Garrett Scapellato, Taylor N. Spence, Katayoun Mansouri, Kevin Wiehe, Nancy Sullivan, Rosemarie Mason, Robert Edwards, Kevin Saunders, Barton F. Haynes, Priyamvada Acharya, Victor Ilevbare, Priyanka Devkota, Yanshun Liu
| Nature Verified
Abstract Henipaviruses, in the Paramyxoviridae family, includes the highly virulent Nipah virus that causes reoccurring outbreaks of deadly disease. Recent discoveries of Henipavirus-like species, including the zoonotic Langya virus, have revealed much higher antigenic diversity than currently characterized and prompted the reorganization of these viruses into the Henipavirus and Parahenipavirus genera.
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Vaccine induction of heterologous HIV-1-neutralizing antibody B cell lineages in humans

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By Wilton B. Williams, S. Munir Alam, Gilad Ofek, Nathaniel Erdmann, David C. Montefiori, Michael S. Seaman, Kshitij Wagh, Bette Korber, Robert Edwards, Katayoun Mansouri, Amanda Eaton, Derek Cain, Mitchell Martin, JongIn Hwang, Xiaozhi Lu, Robert Parks, Maggie Barr, Kara Anasti, Parth Patel, Salam Sammour, Ruth Parsons, Xiao Huang, Jared Lindenberger, Susan K. Fetics, Katarzyna Janowska, Benjamin M. Janus, Anagh Astavans, Christopher Fox, Ipsita Mohanty, Yue Chen, Madison Berry, Hélène Fradin Kirshner, Elizabeth Van Itallie, Kevin Saunders, Kevin Wiehe, Kristen Cohen, M. Juliana McElrath, Lawrence Corey, Priyamvada Acharya, Stephen Walsh, Lindsey R. Baden, Barton F. Haynes, Aria Arus-Altuz, Fangping Cai, Nolan Jamieson, Andrew Foulger, Aurelie Niyongabo, Tyler Evangelous
| Cell Press Verified
Main text (Cell 187, 2919–2934.e1–e10; June 6, 2024) This paper reported the induction of HIV heterologous neutralizing B cell lineages in humans. In reviewing the data in Figure S2 listing the 197 HIV strains tested with the DH1317.4 vaccine-induced bnAb, we noticed that two of the isolates, TRO11 and X1632, were duplicated, i.e., these isolates were tested twice. Thus, the total number of unique viruses tested with the DH1317.4 broad neutralizing antibody (bnAb) has been revised from 197 to 195.
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Nonstabilized SARS-CoV-2 spike mRNA vaccination induces broadly neutralizing antibodies in nonhuman primates

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By R. Dilshan Malewana, Victoria Stalls, Aaron May, Xiaozhi Lu
| Science Magazine Verified
Editor’s summary Many of the approved vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) rely on a stabilized version of the spike protein. However, Malewana et al. show that this stabilization is not needed for elicitation of SARS-CoV-2 spike protein–specific antibody responses, at least in rhesus macaques. Nonstabilized spike mRNA vaccines elicited broadly neutralizing antibodies that could bind to SARS-CoV-2 variants of concern or to other sarbecoviruses.
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Broadly neutralizing antibody induction by non-stabilized SARS-CoV-2 Spike mRNA vaccination in nonhuman primates

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By Victoria Stalls, Aaron May, Xiaozhi Lu, R. Dilshan Malewana
| BioRxiv
Abstract Immunization with mRNA or viral vectors encoding spike with diproline substitutions (S-2P) has provided protective immunity against severe COVID-19 disease. How immunization with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) spike elicits neutralizing antibodies (nAbs) against difficult-to-neutralize variants of concern (VOCs) remains an area of great interest.
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By Zekun Mu, Kevin Wiehe, Kevin Saunders, Rory Henderson, Derek Cain, Robert P. Parks, Katayoun Mansouri, Robert Edwards, Amanda Newman, Xiaozhi Lu, Amanda Eaton, Mattia Bonsignori, David C. Montefiori, Qifeng Han, Diana Martik, Shi-Mao Xia, Sravani Venka
| Cell Reports Verified
Highlights • mRNA-expressed HIV-1 Envs are well folded with optimal stabilizing mutations • mRNA-expressed stabilized Envs show preferential bnAb binding • mRNA-LNP elicit autologous tier 2 neutralizing antibodies with key bnAb mutations • Induced monoclonal antibodies with key mutations neutralize heterologous viruses Summary The success of nucleoside-modified mRNAs in lipid nanoparticles (mRNA-LNP) as COVID-19 vaccines heralded a new era of vaccine development.
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Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

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By Mattia Bonsignori, Tongqing Zhou, Zizhang Sheng, Lei Chen, Feng Gao, S. Munir Alam, Amit Kumar, M. Gordon Joyce, Gabriel Ozorowski, Gwo-Yu Chuang, Chaim A. Schramm, Kevin Wiehe, Todd Bradley, Morgan A. Gladden, Kwan-Ki Hwang, Sheelah Iyengar, Xiaozhi Lu
| Cell Press Verified
FiguresFigure 1CH235 Lineage, with Time of Appearance and Neutralization by Select Members(A) Phylogram of CH235 lineage. Phylogenetic tree is colored by first time (weeks post-infection) from which sequences were obtained. Key members of the CH235 lineage are labeled.
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