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Abstract Aurora B is essential for mitotic progression, yet whether its activity is regulated by tumour metabolism remains unclear. Here we show that Aurora B functions as a sensor of glycolytic activity and is activated through lactate-dependent signalling. Mechanistically, increased lactate production during aerobic glycolysis promotes KAT2A-mediated lactylation of phosphoglycerate kinase 1 (PGK1) at K131. Lactylated PGK1 phosphorylates Aurora B at T232, leading to cell cycle progression.
Keywords SCFA propionate MHC class I STUB1 ubiquitination immune response immune therapy tumor Get full text access Log in, subscribe or purchase for full access. References 1. Sharma, P. ∙ Siddiqui, B.A. ∙ Anandhan, S. ... The Next Decade of Immune Checkpoint Therapy Cancer Discov. 2021; 11:838-857 2. Rosenberg, S.A. ∙ Restifo, N.P. Adoptive cell transfer as personalized immunotherapy for human cancer Science. 2015; 348:62-68 3. Saxena, M. ∙ van der Burg, S.H. ∙ Melief, C.J.M. ...
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