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Xinying Lv

As seen in: Nature, Wiley Online Library
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Articles

Inorganic nitrogen metabolic reprogramming of the gut microbiome drives fecal microbiota transplantation in ulcerative colitis

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By Yinlong Wang, Qihang Hou, Xinying Lv, Huimei Wang, Yan Zhao, Haonan Tong, Yanli Liu, Juan Du, Xiaojun Yang, Shengru Wu, Shuixiang He, Xin Yang, Jiongyan Liu
| Nature Verified
Abstract Although fecal microbiota transplantation (FMT) shows promise for ulcerative colitis (UC), its clinical success appears to be contingent upon the degree of donor microbiota engraftment. Using an LD50-based ecological model, our study reveals that inorganic nitrogen utilization capacity (IN-uc) critically determines gut microbial assembly in high oxidative stress environments, which significantly influences microbial engraftment outcomes.
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Permeable nanoreactor eye drop for enzymatic cascade-mediated treatment for acute retinal injury model mimicking geographic atrophy

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By Jingjing Shen, Haibin Zhao, Yuan Fang, Xinying Lv, Linfu Chen, Yu Miao, Zhiqiang Wu, Nanhui Liu, Qiang Zhang, Qian Chen
| Nature Verified
Abstract Geographic atrophy (GA), the most prevalent form of age-related macular degeneration (AMD), remains clinically challenging due to its complex pathogenesis. Using an acute retinal injury model that mimics GA pathology (oxidative stress-induced retinal apoptosis), we identify enzymatic cascade restoration as a promising therapeutic strategy. To overcome ocular delivery barriers, we engineer zwitterionic nanocages for co-delivering catalase (CAT) and superoxide dismutase (SOD) (Z(CAT&SOD)).
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The Optimized Lipid‐Modified Prodrug for CNV Treatment

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By Xinying Lv, Jingjing Shen, Xinwei Du, Boyu Yue
| Wiley Online Library Verified
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202419263-sup-0001-SuppMat.docx26.3 MB Supporting Information References 1, , , JAMA, J. Am. Med. Assoc. 2024, 331, 147. 2, , , , , , , ACS Nano 2024, 18, 19649. 3, , , , , , , , , , , , , , Nat. Commun. 2022, 13, 374. 4, Cell 2020, 180, 1033. 5, Nat. Rev. Drug Discovery 2015, 14, 820. 6, , , , , , , , , , , , , , , , , , , Sci. Adv. 2023, 9, eabq3104. 7, , , , , , , , , , , , , , , , , , , , , Sci.
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