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Xue Wen Ng on Muck Rack

Xue Wen Ng

As seen in: Nature, PNAS, BioRxiv, Optica
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Articles

The response of mitochondrial position to glucose stimulation in a model system of the pancreatic beta cell

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By Luis Perez, Luís Perez, Xue Wen Ng, David W. Piston, Shankar Mukherji
| BioRxiv
Abstract The compartmentalization of eukaryotic cells into membrane-bound organelles with specific subcellular positioning enables precise spatial and temporal control of cellular functions. While functionally significant mitochondrial localization has been demonstrated in cells such as neurons, it remains unclear how general these cell principles are. Here, we examine the spatial organization of mitochondria within MIN6 pancreatic beta cells under variable glucose conditions.
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Role of Complexin 2 in the regulation of hormone secretion from the islet of Langerhans

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By Xue Wen Ng, Michael R. DiGruccio, Chen Kong, Jeongmin Lee
| BioRxiv
Abstract Regulated secretion of insulin from β-cells, glucagon from α-cells, and somatostatin from δ-cells is necessary for the maintenance of glucose homeostasis. The release of these hormones from pancreatic islet cells requires the assembly and disassembly of the SNARE protein complex to control vesicle fusion and exocytosis. Complexin 2 (Cplx 2) is a small soluble synaptic protein that participates in the priming and release steps of vesicle fusion.
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Disrupting actin filaments enhances glucose-stimulated insulin secretion independent of the cortical actin cytoskeleton

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By Alexander J Polino, Xue Wen Ng, Rebecca Rooks, David W. Piston
| BioRxiv
Thank you for your interest in spreading the word about bioRxiv. NOTE: Your email address is requested solely to identify you as the sender of this article. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has forwarded a page to you from bioRxiv Message Body (Your Name) thought you would like to see this page from the bioRxiv website.
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