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Articles by Ya Su
Microbiota-based modulation of intratumoral cholesterol metabolism for colorectal cancer treatment
Abstract Excess cholesterol accumulates in colorectal cancer (CRC) and promotes its progression, yet systemic cholesterol-lowering has limited benefits and safety concerns. Here we show that redirecting intestinal cholesterol metabolism through the gut microbiota generates a metabolite, 4-cholesten-3-one (4-C-3), which suppresses CRC growth. A screen of microbial cholesterol metabolites showed that 4-C-3 is depleted in faecal and tumour samples from patients with CRC.
NEDD1 stabilization regulated by hUTP14a and FBW7γ axis safeguards mitotic cell fate homeostasis
Abstract Accurate spindle formation is vital for mitotic progression and genomic DNA segregation, with γ-tubulin ring complex (γ-TuRC) mediating microtubule nucleation, and NEDD1 serving as its essential recruitment/anchoring adaptor. However, the mechanisms underlying the regulation of NEDD1 remain largely elusive. Here, we identify a pathway that controls NEDD1 stability during mitosis.
Kinesiophobia and associated factors among lung transplant recipients: a cross-sectional study
Abstract Background: Kinesiophobia is a prominent barrier to physical activity in lung transplant recipients (LTRs). However, research on kinesiophobia of LTRs remains limited. This cross-sectional study aimed to explore the status and associated factors of kinesiophobia in LTRs. Methods: A convenience sample of 200 LTRs from a tertiary hospital’s lung transplant unit was recruited from March to November, 2025. Ultimately, 198 valid questionnaires were included in the statistical analysis.
The impact of SGLT2 inhibitors on renal outcomes in patients with type 2 diabetes and chronic kidney disease: systematic review and meta-analysis
Abstract Objective: To analyze and evaluate the impact of SGLT2 inhibitors on the renal outcomes of patients with type 2 diabetes mellitus and chronic kidney disease, and to provide evidence-based basis for clinical rational treatment. Methods: Relevant literatures on the impact of SGLT2 inhibitors on the renal outcomes of patients with type 2 diabetes mellitus and chronic kidney disease published in domestic and foreign databases were retrieved and collected.
HACC-TNF-α-VLP Nanoparticles Facilitate HSP90-Dependent Antigen Cross-Presentation to Enhance CD8⁺ T Cell and Mucosal Immunity Against Foot-and-Mouth Disease
Back to Journals » International Journal of Nanomedicine » Volume 21 Authors Lv L, Su Y, Chen S, Su W, Yin Y, Ning P, Liu S, Yuan W, Li L Received 23 February 2026 Accepted for publication 10 May 2026 Published 27 May 2026 Volume 2026:21 600992 DOI https://doi.org/10.2147/IJN.S600992 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Prof.
Linkage between IL-23 and coronary arterial lesions in pediatric patients with Kawasaki disease
Abstract Background: Coronary artery lesions (CALs) in Kawasaki disease (KD) are thought to arise from aberrant immune activation and an amplified inflammatory cascade triggered by an unidentified etiologic factor.
Texture and Flavor Improvement of Aged Indica Rice by Integrated Ultrasonication‐Assisted Infrared Cooking via Starch Structures and Water Status Modification
1 Introduction Rice is one of the most widely cultivated agricultural crops globally. Its strategic reserves are crucial for ensuring national food security, stabilizing markets, and supporting rural livelihoods, thus promoting sustainable economic development (Guo et al. 2024).
Exosite-mediated targeting of GSDMB by dimeric granzyme A in lymphocyte pyroptotic killing
Keywords cytotoxic lymphocytes cell killing pyroptosis granzyme A gasdermin B exosite Get full text access Log in, subscribe or purchase for full access. References 1. Jorgensen, I. ∙ Miao, E.A. Pyroptotic cell death defends against intracellular pathogens Immunol. Rev. 2015; 265:130-142 2. Man, S.M. ∙ Karki, R. ∙ Kanneganti, T.D. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases Immunol. Rev. 2017; 277:61-75 3. Shi, J. ∙ Gao, W. ∙ Shao, F.
A Divide and Conquer Algorithm of Bayesian Density Estimation
1 Introduction In an era of real big data, datasets for statistical analysis become extremely large even with storing on a single machine with some difficulty. Even when the data can be stored in one machine, the computational cost would still be intimidating.
Association of interleukin-35 polymorphisms with Kawasaki disease in Chinese children
Kawasaki disease is a leading cause of acquired heart disease in children in the developed world, characterised by acute systemic vasculitis, with a complex aetiology that remains poorly understood. Recent studies have highlighted the potential anti-inflammatory effects of Interleukin-35 in various proinflammatory and cardiovascular conditions.
Associations between multiple acute infarctions and intracranial arterial stenosis with functional outcomes in anterior circulation acute ischaemic stroke reperfusion therapy: results from the China National Stroke Registry III
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A disturbance index-based approach for determining the effective numerical model size for tunnels
Abstract In numerical modelling of tunnelling, the simplified model sizes, typically approximated as six times the tunnel radius, often overlook rock mass quality and underestimate tunnel excavation disturbances, especially for deep tunnels. In this study, we propose a novel approach to determine the effective size of a numerical tunnel model by utilising a rock disturbance index, accounting for poor rock mass quality.
A novel marine predator whale optimization algorithm for global numerical optimization
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Coping Styles Mediated the Association Between Perceived Organizational Support and Resilience in Emergency Nurses Exposed to Workplace Violence: A Cross‐Sectional Study
Conflicts of Interest The authors declare no conflicts of interest. References , , , , , and . 2021. “Workplace Violence in the Emergency Department: A Systematic Review and Meta-Analysis.” Public Health 196: 186–197. https://doi.org/10.1016/j.puhe.2021.02.009. , , , et al. 2020. “Workplace Stress and Resilience in the Australian Nursing Workforce: A Comprehensive Integrative Review.” International Journal of Mental Health Nursing 29, no. 1: 5–34. https://doi.org/10.1111/inm.12662. 2007.
Reduction of oil absorption and acrylamide content in banana slices by infrared frying
Supporting Information Filename Description jsfa14015-sup-0001-Figures.docxWord 2007 document , 2.1 MB Data S1: Supplementary Figures. REFERENCES 1 and , Recent advances in microstructure characterization of fried foods: different frying techniques and process modeling. Trends Food Sci Technol 116: 786–801 (2021). 2, , , and , Microstructure analysis of crust during deep-fat or hot-air frying to understand French fry texture. J Food Eng 298:110484 (2021).
Topological polarization beam splitter based on directional coupling between asymmetric valley photonic crystal waveguides
Compared with symmetric directional couplers (DCs), asymmetric DCs constructed by two or over two different parallel waveguides offer a more flexible structure and allow for easier expansion of mode channels. In this Letter, we propose a kind of asymmetric topological DC based on two different valley photonic crystal waveguides (VPCWs).
A 3D bioprinted antibacterial hydrogel dressing of gelatin/sodium alginate loaded with ciprofloxacin hydrochloride
CONFLICT OF INTEREST STATEMENT The authors have no conflicts of interest. REFERENCES 1, , , , & (2022). Progress in hydrogels for skin wound repair. Macromolecular Bioscience, 22(7), 2100475. 2, , , , , , , & (2022). Chitosan/alginate hydrogel dressing loaded FGF/VE-cadherin to accelerate full-thickness skin regeneration and more normal skin repairs. International Journal of Molecular Sciences, 23(3), 1249. 3, , , & (2022). Antibacterial biomaterials for skin wound dressing.
Relatively Unworthy Victims? Middle-Aged Women as Rape Survivors
Get full access to this article View all access and purchase options for this article. References Abrams D., Viki G. T., Masser B., Bohner G. (2003). Perceptions of stranger and acquaintance rape: The role of benevolent and hostile sexism in victim blame and rape proclivity. Journal of Personality and Social Psychology, 84(1), 111–125. https://doi.org/10.1037/0022-3514.84.1.111 Anderson I., Doherty K. (2007).
Tailoring the physicochemical properties of starch: impact of integrated ultrasonic and ethanol pretreatment on the oil uptake of infrared fried ginkgo seeds
Background The structural changes of starch would have a more crucial impact on oil absorption and quality changes in starch-rich fruits and vegetables during frying process with enhanced heat transfer (such as infrared frying). Currently, the influence of integrated ultrasonic and ethanol (US+ethanol) pretreatment on the oil uptake in infrared fried (IF) ginkgo seeds was evaluated regarding the modifications in physicochemical properties of starch.
Perceived organizational support, self‐efficacy and cognitive reappraisal on resilience in emergency nurses who sustained workplace violence: A mediation analysis
CONFLICT OF INTEREST STATEMENT The authors declare that they have no competing interests. REFERENCES , & (2022). Critical clinical events and resilience among emergency nurses in 3 trauma hospital-based emergency departments: A cross-sectional study. Journal of Emergency Nursing, 48(5), 525–537. https://doi.org/10.1016/j.jen.2022.05.001 , , , , , & (2021). Workplace violence in the emergency department: A systematic review and meta-analysis. Public Health, 196, 186–197.
Frailty and social isolation before and during the coronavirus disease 2019 pandemic among older adults: A path analysis
1 INTRODUCTION Studies conducted before the coronavirus disease 2019 (COVID-19) pandemic showed that social isolation is associated with decreased physical activity and depression (Schrempft et al., 2019). The COVID-19 pandemic has since had a worldwide impact on public health. Older adults were advised to maintain social distance or stay at home and isolate themselves from people who could infect them.
Carrier Doping Modulate Magnetoelectronic, and Magnetic Anisotropic Properties of Two-Dimensional MSi2N4 (M = Cr, Mn, Fe, and Co) Monolayers
Carrier Doping Modulate Magnetoelectronic, and Magnetic Anisotropic Properties of Two-Dimensional MSi2N4 (M = Cr, Mn, Fe, and Co) Monolayers Carrier Doping Modulate Magnetoelectronic, and Magnetic Anisotropic Properties of Two-Dimensional MSi2N4 (M = Cr, Mn, Fe, and Co) Monolayers You have access to this article This article has not yet been cited.
Compact topological polarization beam splitter based on all-dielectric fishnet photonic crystals
Abstract Conventional polarization beam splitters (PBSs) suffer energy loss and signal distortion due to backscattering caused by disturbances. Topological photonic crystals provide backscattering immunity and anti-disturbance robustness transmission owing to the topological edge states. Here, we put forward a kind of dual-polarization air hole-type fishnet valley photonic crystal with a common bandgap (CBG).
Association between Sedentary Behavior during Leisure Time and Excessive Weight in Chinese Children, Adolescents, and Adults
Abstract : (1) Background: Sedentary behavior is increasing in all age groups and is one of the most common lifestyles that is a risk factor for overweight and obesity; however, few studies have evaluated the impact of leisure-time sedentary behavior on overweight and obesity.
Postmodification Strategy to Modulate the Photoluminescence of Carbon Dots from Blue to Green and Red: Synthesis and Applications
Postmodification Strategy to Modulate the Photoluminescence of Carbon Dots from Blue to Green and Red: Synthesis and Applications Carbon dots (CDs) have attracted increasing attention in bioimaging and theranostic because of their unique merits including small size, high photostability, good biocompatibility and excellent hydrophilcity.
Left atrial remodeling, hypertrophy and fibrosis in mouse models of heart failure
Publication HistoryPublished online: June 21, 2017Accepted: June 16, 2017; Received in revised form: June 15, 2017; Received: February 16, 2017;
PDLIM5 links kidney anion exchanger 1 (kAE1) to ILK and is required for membrane targeting of kAE1
The following antibodies were used in this study: Bric-170 (mouse monoclonal, IBGRL 9540, recognizing AE1); anti-PDLIM5-nt (rabbit polyclonal, Abcam ab83060), anti-PDLIM5-mid (rabbit polyclonal, Sigma HPA016740) and anti-PDLIM5-ct (rabbit monoclonal, Bethyl Laboratories A301-704A) – all PDLIM5 specific; anti-integrin linked kinase (ILK) (rabbit monoclonal, Abcam ab76468); anti-CD63 (mouse monoclonal, Abcam ab8219); anti-?1 (mouse monoclonal, recognizing ?1 subunit of Na+, K+-ATPase,...
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