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Yahui Yan

As seen in: Nature, BioRxiv, Cell Press, The Journal of Biological Chemistry
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Articles by Yahui Yan

A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum

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By Lisa Neidhardt, Joanne Tung, Miriam Kuchersky, Jakub Milczarek, Vasileios Kargas, Katherine Stott, Rina Rosenzweig, David Ron, Yahui Yan
| Cell Press Verified
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Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the Integrated Stress Response

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By Yahui Yan, Maithili Shetty, Heather Harding, Ginto George
| BioRxiv
Abstract Dephosphorylation of pSer51 of the α subunit of translation initiation factor 2 (eIF2αP) terminates signalling in the integrated stress response (ISR). A trimeric mammalian holophosphatase comprised of a PP1 catalytic subunit, the conserved C-terminally located ~70 amino acid core of a substrate-specific regulatory subunit (PPP1R15A/GADD34 or PPP1R15B/CReP) and G-actin (an essential co-factor) efficiently dephosphorylate eIF2αP in vitro.
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Structural basis for the specificity of renin-mediated angiotensinogen cleavage

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By 'S Choice, Yahui Yan, Aiwu Zhou, Wellcome Trust
| The Journal of Biological Chemistry Verified
Yahui Yan (严 亚慧)‡, Aiwu Zhou (周 爱武)§1, Robin W. Carrell‡ and Randy J.
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Structural basis for the specificity of renin-mediated angiotensinogen cleavage

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By 'S Choice, Yahui Yan, Aiwu Zhou, Wellcome Trust
| The Journal of Biological Chemistry Verified
Yahui Yan (严 亚慧)‡, Aiwu Zhou (周 爱武)§1, Robin W. Carrell‡ and Randy J.
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Structural basis for the specificity of renin-mediated angiotensinogen cleavage

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By Yahui Yan, Randy Read, Aiwu Zhou, Robin W. Carrell
| The Journal of Biological Chemistry Verified
Yahui Yan1, Aiwu Zhou2, Robin W. Carrell3 and Randy J.
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PDLIM5 links kidney anion exchanger 1 (kAE1) to ILK and is required for membrane targeting of kAE1

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By Juan Li, Ya Su, Thomas F. Hiemstra, Yahui Yan
| Nature Verified
The following antibodies were used in this study: Bric-170 (mouse monoclonal, IBGRL 9540, recognizing AE1); anti-PDLIM5-nt (rabbit polyclonal, Abcam ab83060), anti-PDLIM5-mid (rabbit polyclonal, Sigma HPA016740) and anti-PDLIM5-ct (rabbit monoclonal, Bethyl Laboratories A301-704A) – all PDLIM5 specific; anti-integrin linked kinase (ILK) (rabbit monoclonal, Abcam ab76468); anti-CD63 (mouse monoclonal, Abcam ab8219); anti-?1 (mouse monoclonal, recognizing ?1 subunit of Na+, K+-ATPase,...
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