Yan Pan
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Articles by Yan Pan
Transport–Reaction–Signal Coupling in Lateral Flow Assays for Next-Generation Point-of-Care Diagnostics
1 Introduction Recent global public health crises, including SARS, Ebola, and COVID-19, have accelerated interest in shifting part of diagnostic practice from centralized laboratory analysis toward point-of-care testing (POCT) [1-3]. During large-scale outbreaks, the limitations of conventional laboratory workflows, including restricted throughput, logistical complexity, and delayed turnaround, become particularly apparent.
Ubiquitin marks abnormal glycogen for destruction to protect the brain, study finds
Brain sections showing accumulation of polyglucosan (red) in RNF213 deficient animals. Credit: Felix Randow's group Researchers at the University of Cambridge and the MRC Laboratory of Molecular Biology have discovered a previously unknown cellular defense system that protects the brain from abnormal glycogen accumulation, which is linked to severe neurological disorders.
Extraordinary Tibetan Plateau early-winter heating drove record-breaking winter precipitation in California and adjacent regions
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share This article has 0 eLetter . Abstract California and adjacent regions received record-breaking precipitation in the winters of 2016–2017 and 2022–2023, causing extraordinary damage and severe societal impacts.
Cumulative disruption of regulatory genes precedes whole-chromosome gains in acute myeloid leukemia
To the Editor Whole-chromosome gains are common in myeloid malignancies, yet the genomic states that predispose cells to their emergence remain unclear. Genes whose perturbation induces phenotypically obvious numerical chromosomal instability in functional screens are rarely mutated in cancer patients [1, 2], suggesting that subtler indirect drivers may be at play.
A pangenome of tetraploid wheat reveals the genetic architecture underlying domestication and genomic diversity for breeding
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Abstract Tetraploid wheat (Triticum turgidum L., BBAA), a key pasta crop, serves as an untapped genetic resource with rich genomic diversity for hexaploid bread wheat improvement. Here we de novo assembled 12 genomes spanning all 10 recognized tetraploid wheat (genome BBAA) subspecies, and a graph-based pangenome was constructed.
By Jianxin Bian, Guang Yang, Dong Xu, Yan Zhang, Guifen Zhang, Zhen Qin, Shuangxing Zhang, Yiqiao Wang, Mengmeng Jiang, Yan Pan, Bin Chen, Fangyu Liu, Yuqing Lu, Shuai Dominique Ding, Jiabo Wang, Can Yuan, Yongming Chen, Shoucheng Liu, Hang He, Shuai Wang, Qidi Zhu, Shisheng Chen, Qing Sang, Xing Wang Deng, Hude Mao, Xiaojun Nie, Baoxing Song, Yanzhe Jia
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Nature
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Correlation of Glomerular MBL Deposition with the Clinicopathology and Prognosis of Idiopathic Membranous Nephropathy: A PLA2R Subgroup Analysis
Back to Journals » International Journal of General Medicine » Volume 19 Original Research Nephrology Authors Pan Y, Zhao Y , Wu X , Chen B, Lu M, Shao D, Liu L, Chen W Received 26 June 2026 Accepted for publication 25 September 2026 Published 23 October 2026 Volume 2026:19 631116 DOI https://doi.org/10.2147/IJGM.S631116 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Professor David E.
Long-distance discrete-modulated continuous-variable quantum key distribution over 126.56 km of fiber with a local local oscillator
Abstract Discrete modulation is a practical and device-friendly solution for high-speed continuous-variable quantum key distribution (CV-QKD), offering strong compatibility with existing coherent optical communication systems. However, its achievable transmission distance has remained considerably shorter than that of Gaussian-modulated protocols, limiting its practical deployment.
Evaluation of CD16 , CD32 , CD40 , and CD152 polymorphisms in immune thrombocytopenia patients: a systematic review, meta-analysis, and trial sequential analysis
Abstract Background: Understanding the role of genetic polymorphisms in cluster of differentiation (CD)-related genes is crucial for elucidating susceptibility to immune thrombocytopenia (ITP). This study evaluates the polymorphisms of CD16, CD32, CD40, and CD152 in ITP patients through a systematic review, meta-analysis, and trial sequential analysis.
Gaussian-modulated continuous-variable quantum key distribution over 60 km fiber using an integrated silicon photonic receiver
Fully integrated photonic continuous-variable quantum key distribution is a promising route toward compact and scalable secure optical links, yet the achievable transmission distance has been limited by the performance of integrated receiver chips and excess noise suppression methods. Here, we demonstrate a Gaussian-modulated continuous-variable quantum key distribution system with an integrated silicon photonic receiver, operating over 60 km.
Support at Work, Capitalization at Home: The Interpersonal Effects of Family-Supportive Supervisor Behaviors
1 Introduction The rise of dual-earner households and the increasing integration of work and family domains have made the pursuit of work–family balance both more essential and more complex (Ererdi et al. 2024; Kossek et al. 2023). In this evolving landscape, supervisors are expected to play a critical role in supporting employees as they navigate competing demands from work and home.
Ubiquitination of DDX21 by HERC2 induces a dormancy-like phenotype via the NUCKS1-p21/p27 axis to promote radio-resistance in colorectal cancer cells
Abstract Cellular dormancy in colorectal cancer (CRC) significantly contributes to therapeutic resistance, tumor recurrence, and metastasis, resulting in poor prognosis. However, the underlying molecular mechanisms remain poorly understood. Here, we used spheroid culture combined with serum deprivation to enrich and identify dormancy-like CRC cells in vitro and characterized their dormancy-like phenotype by G0/G1 phase arrest, suppressed proliferation and radio-resistance.
High expression of STAT3 and PD-L1 predicts poor prognosis for laryngeal squamous cell carcinoma
Abstract Laryngeal squamous cell carcinoma (LSCC) ranks among the most prevalent malignant tumors in the head and neck region. Signal transducer and activator of transcription 3 (STAT3) belongs to the family of cytoplasmic latent transcription factors, which has been discovered to be activated in various human cancers and is linked to cancer progression, lymph node metastasis, and unfavorable prognosis.
Comparative Analysis of Clinicopathological Features and Outcomes Between Kidney-Limited and Systemic Thrombotic Microangiopathy: A Study Based on a Semiquantitative Pathological Scoring System
Back to Journals » International Journal of Nephrology and Renovascular Disease » Volume 19 Authors Pan Y, Zhao Y , Li X , Wu X , Chen B, Lu M, Shen R, Chen W, Liu L Received 19 February 2026 Accepted for publication 11 August 2026 Published 30 August 2026 Volume 2026:19 604159 DOI https://doi.org/10.2147/IJNRD.S604159 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Yin Wang Yan Pan, Yongxin Zhao, Xi Li, Xueping...
Epigenetic regulation of NDGA and its synergistic inhibition with EZH2 inhibitors in prostate cancer via NRP1 - Acta Pharmacologica Sinica
Abstract Epigenetic modulating drugs are emerging as promising cancer treatments. We previously showed that a natural compound, nordihydroguaiaretic acid (NDGA), exerted anti-prostate cancer effects in vitro and in vivo. In this study, we elucidated the anticancer mechanisms of NDGA against prostate cancer.
Structural characterization of endogenous microprotein EMBOW reveals an alternative MRT motif for WDR5‐interacting site recognition
Conflict of interest The authors declare no conflict of interest. Peer review The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/febs.70450. Data availability statement The atomic coordinates and structure factors for the WDR5-EMBOW, WDR5-EMBOW_T3V, WDR5-EMBOW_GS, WDR5-RBM15, and WDR5-ZSCAN10 complexes have been deposited in the Protein Data Bank with the accession numbers 9KFM, 9KFN, 9KFO, 9L0T, and 9L0V.
Hypoxic tumor exosomes suppress macrophage inflammation and ferroptosis via NDUFV2 to enhance bystander tumor radioresistance - Cell Death & Disease
Abstract Hypoxia-induced radioresistance presents a major barrier to effective radiotherapy of non-small cell lung cancer (NSCLC), while the underlying role of macrophages remaining elusive.
Recent Advances in Ammonia Decomposition for Hydrogen Production: Methods, Mechanisms, and Trends in Photocatalysts and Electrocatalysts
With the global transition toward a sustainable energy landscape, hydrogen energy has emerged as a pivotal solution due to its renewability and zero-carbon emissions, offering a promising alternative to fossil fuels.
Unveiling the Q‐Markers of Viscum coloratum (Kom.) Nakai: Enhancing Clinical Efficacy for the Treatment of Rheumatoid Arthritis
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description bmc70277-sup-0001-Supplementary_Material.docxWord 2007 document , 375.9 KB Figure S1: The base peak intensity (BPI) chromatograms of Liaoning, Inner Mongolia, Jilin, and Hebei provinces for Viscum coloratum (Kom.) Nakai in negative ion mode.
Frontiers | Mesenchymal stem cell-derived small extracellular vesicles (sEVs) as a therapy for sepsis-related liver injury: evidence from a systematic review and meta-analysis
Department of Blood Transfusion, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People’s Hospital, Quzhou, Zhejiang, China Background: Sepsis-induced liver injury (SILI) is critical in the progression of high morbidity and mortality associated with sepsis which ends in hepatic dysfunction and multi-organ failure. Mesenchymal stem cell–derived small extracellular vesicles (MSC-sEVs) are valued for their anti-inflammatory and regenerative potential as favorable strategy.
Dual Impact of Relational Embeddedness on Expertise and Administrative Coordination
Practical Applications This study can help project managers distinguish between expertise coordination and administrative coordination, and adopt more tailored and effective management practices through internal and external relational embeddedness. First, internally, practices such as team building, internal communication strategies, and conflict resolution are crucial. Externally, stakeholder engagement, boundary spanning, and strategic alliance management are more relevant.
Frontiers | Effects of whole-body vibration training on inflammatory markers and lipid profiles in adults: a systematic review and meta-analysis of randomized controlled trials
1School of Sports Training, Wuhan Sports University, Wuhan, China 2School of Physical Education, Wuhan Sports University, Wuhan, China Objective: The aim of this study was to synthesize existing randomized controlled trials (RCTs) to investigate the effects of whole-body vibration (WBV) training on inflammatory markers and lipid profiles in adults.
Can indwelling pleural catheters provide additional benefits in elderly heart failure patients with pleural effusion? A real-world retrospective multicenter analysis
Abstract Background: Pleural effusion (PE) is a common presentation in patients with congestive heart failure. Evidence on the necessity of therapeutic pleural drainage (PD) remains conflicting, highlighting a gap in optimal care for patients. This study aimed to compare standard diuretic therapy (SDT) within guideline-directed medical therapy (GDMT) versus PD in elderly acute heart failure (AHF) patients with moderate PE.
Efficacy and Safety of Rituximab in Treating Adult Patients with Minim
Back to Journals » Drug Design, Development and Therapy » Volume 19 Authors Zhao YX , Li X , Cheng X , Pan Y, Liu L Received 26 June 2025 Accepted for publication 27 October 2025 Published 27 November 2025 Volume 2025:19 Pages 10571—10587 DOI https://doi.org/10.2147/DDDT.S549834 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Tuo Deng Yong Xin Zhao, Xi Li, Xu Cheng, Yan Pan, Lei Liu Department of Nephrology, The...
ElixirSeeker: A Machine Learning Framework Utilizing Fusion Molecular Fingerprints for the Discovery of Lifespan‐Extending Compounds
1 Introduction The demand for anti-aging products and preventive medicines is constantly rising as the worldwide population ages. Various pharmacological approaches have been shown to increase lifespan and attenuate age-related diseases (Scheen 2018; Zhu et al. 2019; Dehghan et al. 2019; Strong et al. 2020; Cabreiro et al. 2013; Singh et al. 2023; Chaib et al. 2022; Martel, Ojcius, et al. 2020).
Remaining Useful Life Prediction Based on Wear Monitoring with Multi-Attribute GAN Augmentation
1. Introduction The Remaining Useful Life (RUL) can be defined as the time interval from the current operational state to the end of its service life (i.e., the scheduled oil replacement point) [1,2]. Accurate RUL prediction is a critical enabler for preventive maintenance (PM) strategies, capturing the machinery’s health to balance reliability assurance and cost-effectiveness.
Impact of comprehensive nursing on operation time of myomectomy and intraoperative blood loss of pregnant women with co-existing uterine myoma
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Cellular senescence-associated gene IFI16 promotes HMOX1-dependent evasion of ferroptosis and radioresistance in glioblastoma - Nature Communications
Abstract Glioblastoma multiforme (GBM) remains a therapeutic challenge due to its aggressive nature and recurrence. This study establishes a radioresistant GBM cell model through repeated irradiation and observes a cellular senescence-like phenotype in these cells. Comprehensive genomic and transcriptomic analyses identify IFI16 as a central regulator of this phenotype and contributes to radioresistance.
L-Theanine Extends the Lifespan of Caenorhabditis elegans by Reducing the End Products of Advanced Glycosylation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Directing cellular transitions on gene graph-enhanced cell state manifold
Abstract A select few genes act as pivotal drivers in the process of cell state transitions. However, finding key genes involved in different transitions is challenging. To address this problem, we present CellNavi, a deep learning-based framework designed to predict genes that drive cell state transitions.
Letter for the article A Study on the Current Situation and Related Fa
Back to Journals » International Journal of General Medicine » Volume 17 Authors Zhang J, Pan Y Received 26 October 2024 Accepted for publication 6 November 2024 Published 19 November 2024 Volume 2024:17 Pages 5415—5416 DOI https://doi.org/10.2147/IJGM.S503136 Checked for plagiarism Yes Editor who approved publication: Dr Redoy Ranjan Jiong Zhang,1 Yan Pan2 1School of Medicine, Henan University of Chinese Medicine, Zhengzhou, People’s Republic of China; 2The First Affiliated Hospital, Henan...
Single-Cell Hypertrophy Promotes Contractile Function of Cultured Human Airway Smooth Muscle Cells via Piezo1 and YAP Auto-Regulation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Caenorhabditis elegans CYP33 Family in Eicosanoid Regulation, Xenobiotic Metabolism, Nanotoxicity and Spermatogenesis
Conflicts of Interest The authors declare no conflicts of interest. References , , , and . 2021. “Benzo[a]pyrene and Caenorhabditis Elegans: Defining the Genotoxic Potential in an Organism Lacking the Classical CYP1A1 Pathway.” Archives of Toxicology 95, no. 3: 1055–1069. https://doi.org/10.1007/s00204-020-02968-z. , , and . 2008.
The Effect of Drugs on the Intestinal Microbiota in Crohn’s Disease
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Structural insights into the recognition of purine‐pyrimidine dinucleotide repeats by zinc finger protein ZBTB43
Conflict of interest The authors declare no conflict of interest. References 1 & (1953) Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature 171, 737–738. 2, , , , , & (1979) Molecular structure of a left-handed double helical DNA fragment at atomic resolution. Nature 282, 680–686. 3 (2020) Simple repeats as building blocks for genetic computers. Trends Genet 36, 739–750. 4 & (2003) Timeline: Z-DNA: the long road to biological function. Nat Rev Genet 4, 566–572.
Base-Promoted Tandem Ring-Opening/Ring-Closing of N-Alkynyl-2-oxazolidinones Enables Facile Synthesis of 2-Oxazolines
Base-Promoted Tandem Ring-Opening/Ring-Closing of N-Alkynyl-2-oxazolidinones Enables Facile Synthesis of 2-Oxazolines A K2CO3-promoted tandem ring-opening/ring-closing of N-alkynyl-2-oxazolidinones has been described, affording 2-oxazolines in 42-99% yields without column chromatography isolation.
Optimisation of Not-from-Concentrate Goji Juice Processing Using Fuzzy Mathematics and Response Surface Methodology and Its Quality Assessment
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
ElixirSeeker: A Machine Learning Framework Utilizing Attention-Driven Fusion of Molecular Fingerprints for the Discovery of Anti-Aging Compounds
Abstract Despite the growing interest in anti-aging drug development, high cost and low success rate pose a significant challenge. We present ElixirSeeker, a new machine-learning framework designed to help speed up the discovery of potential anti-aging compounds by utilizing the attention-driven fusion of molecular fingerprints. Our approach integrates molecular fingerprints generated by different algorithms and utilizes XGBoost to select optimal fingerprint lengths.
WormCNN-Assisted Establishment and Analysis of Glycation Stress Models in C. elegans: Insights into Disease and Healthy Aging
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Source monitoring for plug-and-play continuous-variable quantum key distribution
Continuous-variable quantum key distribution (CV-QKD) with plug-and-play design offers a promising route in simplifying the system implementation and shows intriguing prospects for quantum access network applications.
Investigation of Bus Shelters and Their Thermal Environment in Hot-Humid Areas-A Case Study in Guangzhou
1. Introduction A rapid global urbanization process has occurred in the past twenty years [1], the economic aggregate has continuously reached a new level, and people’s living standards have continued to improve.
[2407.20619] ATI-CTLO:Adaptive Temporal Interval-based Continuous-Time LiDAR-Only Odometry
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DOA Estimation on One-Bit Quantization Observations through Noise-Boosted Multiple Signal Classification
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Introducing contemporary language while respecting tradition. Stellar Island by SpActrum
Project description by SpActrum Stellar Isle, covering approximately 1,200 square metres, stands as the most significant new cultural and leisure building in Shaoxing Chaichanglong. This area represents the first organic renewal zone in the old town of Shaoxing, situated opposite the former residence of the female revolutionist Qiu Jin and overlooking Pagoda Hill to the north. The total area spans 23,500 square metres.
Development of Rapid Isothermal Detection Methods Real‐Time Fluorescence and Lateral Flow Reverse Transcription Recombinase‐Aided Amplification Assay for Bovine Coronavirus
Conflicts of Interest The authors declare that there are no conflicts of interest regarding the publication of this paper. References 1 , , , and , Coronavirus infection of the bovine respiratory tract, Veterinary Microbiology. (1984) 9, no. 5, 425–434, https://doi.org/10.1016/0378-1135(84)90063-4, 2-s2.0-0021202211. 2 and , Comparative pathogenesis of bovine and porcine respiratory coronaviruses in the animal host species and SARS-CoV-2 in humans, Journal of Clinical Microbiology. (2020) 58, no.
The VP1/2 Protein of a New Recombinant PRV Strain Promotes the Infectivity and Pathogenicity of PRV in Northeastern China
Conflicts of Interest The authors have no potential conflicts of interest to declare. Supporting Information Filename Description tbed1575103-sup-0001-f1.docxWord 2007 document , 11.6 MB Supplementary 1 Table S1: PRV strains used in this study. Table S2: PRV strains used in this study. Table S3: analysis of CH/HLJPRVJ/2023 recombinant evolution. tbed1575103-sup-0002-f2.docxWord 2007 document , 2.3 MB Supplementary 2 Figure S1: homology analysis of the CH/HLJPRVJ/2023 strain and other PRV strains.
Prominence of microbiota to predict fibrous stenosis in Crohn's diseas
Back to Journals » Journal of Inflammation Research » Volume 18 Authors Yang X , Pan Y, Gao CP, Li H, Zhang YH, Huang CL, Cao L, Xiao SY , Zhou Z Received 29 May 2024 Accepted for publication 28 November 2024 Published 5 February 2025 Volume 2025:18 Pages 1413—1423 DOI https://doi.org/10.2147/JIR.S480473 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Tara Strutt Xue Yang,* Yan Pan,* Cai-Ping Gao, Hang Li,...
Fluorescent‐protein co‐expression to select CHO cells expressing high quantities of vaccine antigens
CONFLICT OF INTEREST STATEMENT All authors are employees of the GSK group of companies. Supporting Information Filename Description biot202300671-sup-0001-FigureS1-S3.docx1.2 MB Supporting Information REFERENCES 1, , , , , , , , , & (2024). When will we have a clone? An industry perspective on the typical CLD timeline. Biotechnology Progress, e3449. 2, , , , , , & (2019). Mitochondrial membrane potential identifies cells with high recombinant protein productivity.
Development of FRET Biosensor to Characterize CSK Subcellular Regulation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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