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Yangfei Xing

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Articles

Dimerization of MICU Proteins Controls Ca2+ Influx through the Mitochondrial Ca2+ Uniporter

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By Jia Wang, Zhenzhen Nie, Yangfei Xing, Mingfei Wang
| Cell Press Verified
Highlights • Structures of human MICU2 and MICU3 are determined • The N-domain topology of MICU2 (or MICU3) is distinct from that of MICU1 • Distinct N-domains determine the different functions of MICU proteins • Mechanism of mitochondrial Ca2+ uptake regulation by MICU proteins is proposed Summary The mitochondrial Ca2+ uniporter complex (MCUC) is responsible for Ca2+ influx into the mitochondrial matrix, playing critical roles in various mitochondrial functions.
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