Yanying Yang
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Clinical outcomes of intrathecal anti-PD-1 therapy with or without whole-brain radiotherapy in melanoma leptomeningeal metastasis: a multicenter retrospective study
Abstract Background: Leptomeningeal metastases (LM) from melanoma are rare and associated with dismal outcomes. Intrathecal PD-1 antibody therapy has shown encouraging activity in LM. Radiotherapy may enhance tumor immunogenicity and potentially augment immune checkpoint blockade within the central nervous system. The efficacy and safety of combining intrathecal PD-1 antibodies with whole-brain radiotherapy (WBRT) in melanoma LM remain unclear.
Immunometabolite L-2-HG promotes epigenetic modification of exhausted T cells and improves anti-tumor immunity
ResearchImmunologyMetabolism Open Access | 10.1172/jci.insight.174600 JCI Insight. https://doi.org/10.1172/jci.insight.174600. Copyright © 2025, Yang et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Performance of artificial intelligence in detecting the chronic total occlusive lesions of coronary artery based on coronary computed tomographic angiography
Have a website account?Log In orRegister for exclusive website content. Home / Vol 14, No 4 (August 31, 2024) / Performance of artificial intelligence in detecting the chronic total occlusive lesions of coronary artery based on coro...
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