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Articles by Yawei Du
Efficacy and safety of spleen-strengthening and phlegm-resolving herbal therapy for residual dizziness after repositioning of benign paroxysmal positional vertigo: a systematic review and meta-analysis of randomized controlled trials
Abstract Introduction: Spleen-strengthening and phlegm-resolving (SSPR) herbal therapy, a classical core approach in traditional Chinese medicine (TCM) has been widely applied to treat residual dizziness (RD) after canalith repositioning procedures for benign paroxysmal positional vertigo. This systematic review aims to comprehensively evaluate its clinical efficacy and safety.
Promoting Nerve Regeneration via Injectable Immune‐Engineered Short‐Fibers for Prevent Postoperative Pain
Conflict of Interest The authors declare no conflict of interest.Fig.4A is created using Figdraw (www.figdraw.com). Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References 1, , , , , , , Anesthesiology 2009, 111, 490. 2, , Anesthesiology 2009, 111, 464. 3, , , , , Ann. Surg. 2013, 257, 403. 4, , , , , , Scandinavian J. Pain 2019, 20, 95. 5, , , , , , , , , PLoS One 2020, 15, 0229530.
Decursin‐Loaded Nanovesicles Target Macrophages Driven by the Pathological Process of Atherosclerosis
1 Introduction Atherosclerosis (AS) is a chronic inflammatory disease that substantially contributes to major cardiovascular events, including ischemic heart disease and stroke.[1, 2] The pathophysiology of AS is complex and primarily involves vascular endothelial injury, lipid accumulation, and a self-perpetuating cycle of inflammatory responses, which together drive the formation and progression of atherosclerotic plaques.[3] Dyslipidemia, particularly elevated low-density lipoprotein (LDL)...
Urban Road Anomaly Monitoring Using Vision-Language Models for Enhanced Safety Management
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
In Situ Proefferocytosis Microspheres as Macrophage Polarity Converters Accelerate Osteoarthritis Treatment
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202405236-sup-0001-SuppMat.docx9.6 MB Supporting Information References 1, , J. Clin. Invest. 2012, 122, 787. 2, , , , Immunol. Res. 2012, 53, 11. 3, , , , , , , , , , J. Ethnopharmacol. 2024, 325, 117838. 4, , , , , , , , , , , , Biomed Res. Int. 2022, 2022, 6871269. 5, , Nat. Rev. Drug Discovery. 2022, 21, 601. 6, , , Pharmacol. Ther. 2021, 227, 107893. 7, , , , , , , , , , , , , Science.
Application of Distributed Collaborative Optimization in Building Multi-Energy Complementary Energy Systems
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Dynamic Simulation of Carbon Emission Peak in City-Scale Building Sector: A Life-Cycle Approach Based on LEAP-SD Model
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Targeting Bacterial Persisters via Reactive Oxygen Species‐Generating Hydrogel Microspheres
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202405199-sup-0001-SuppMat.docx2 MB Supporting Information References 1, , , Nat. Rev. Microbiol. 2021, 19, 256. 2, , , , , , , , , , Proc. Natl. Acad. Sci. USA 2023, 120, e2208344120. 3, , Mol. Syst. Biol. 2023, 19, e11320. 4, Emerg. Microbes. Infect. 2014, 3, e3. 5, , , , , Nat. Rev. Microbiol. 2015, 13, 298. 6, , , , , , , , , Bioact. Mater. 2022, 16, 134. 7, , , , , , Mol. Syst. Biol. 2016, 12, 882.
Targeting Bacterial Persisters via Reactive Oxygen Species‐Generating Hydrogel Microspheres
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202405199-sup-0001-SuppMat.docx2 MB Supporting Information References 1, , , Nat. Rev. Microbiol. 2021, 19, 256. 2, , , , , , , , , , Proc. Natl. Acad. Sci. USA 2023, 120, e2208344120. 3, , Mol. Syst. Biol. 2023, 19, e11320. 4, Emerg. Microbes. Infect. 2014, 3, e3. 5, , , , , Nat. Rev. Microbiol. 2015, 13, 298. 6, , , , , , , , , Bioact. Mater. 2022, 16, 134. 7, , , , , , Mol. Syst. Biol. 2016, 12, 882.
Depicting the regulatory role of JZOL on TRP channels in the treatment of Acute Bronchitis based on the combination of clinical trials, computational analysis and in vivo experiments
The authors have declared no competing interest.
Reverse Osmosis with Intermediate Chemical Demineralization: Scale Inhibitor Selection, Degradation, and Seeded Precipitation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase - Nature Communications
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Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class with drug-like physical parameters and a synthetically accessible scaffold.
By Stanley C. Xie, Yinuo Wang, Craig Morton, Riley D. Metcalfe, Elyse Dunn, Eva S. Istvan, Joon Sung Park, Tomas Yeo, Mathamsanqa N. Bhebhe, Peter Rutledge, Luiz C Godoy, Sumanta Dey, Yawei Du, Nicholas Williamson, Patrick Thomson, Derek Tan, Jacquin C. Niles, Daniel Goldberg, Jeremy Burrows, David A Fidock, Matthew Todd, Nutpakal Ketprasit, Tanya Puhalovich, Gerry Shami
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Nature
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Intestine‐targeted Explosive Hydrogel Microsphere Promotes Uric Acid Excretion for Gout Therapy
Purines could be converted into uric acid in the gut microenvironment, triggering metabolic diseases, especially gout, while the uric acid excretion is impaired. However, increasing uric acid excretion remains a challenge.
Adsorption behaviors and mechanisms of porous hypercrosslinked polymers with adjustable functional groups toward doxycycline hydrochloride from water
Supporting Information Filename Description app54818-sup-0001-Supinfo.docWord document, 1.9 MB Data S1: Supplementary Information REFERENCES 1, , , , J. Environ. Chem. Eng. 2021, 9, 106183. 2, , , , , , , J. Clean. Prod. 2023, 394, 136271. 3, , , , , , Microporous Mesoporous Mater. 2019, 288, 109601. 4, , , , , J. Environ. Chem. Eng. 2021, 9, 104796. 5, , , , , , , , , J. Environ. Manag. 2022, 320, 115944. 6, , , , , , , , , , , , , , , , , , , , , , J. Hazard. Mater. 2019, 380, 120885. 7, , , , , , , Sci.
Adsorption behaviors and mechanisms of porous hypercrosslinked polymers with adjustable functional groups toward doxycycline hydrochloride from water
Supporting Information Filename Description app54818-sup-0001-Supinfo.docWord document, 1.9 MB Data S1: Supplementary Information REFERENCES 1, , , , J. Environ. Chem. Eng. 2021, 9, 106183. 2, , , , , , , J. Clean. Prod. 2023, 394, 136271. 3, , , , , , Microporous Mesoporous Mater. 2019, 288, 109601. 4, , , , , J. Environ. Chem. Eng. 2021, 9, 104796. 5, , , , , , , , , J. Environ. Manag. 2022, 320, 115944. 6, , , , , , , , , , , , , , , , , , , , , , J. Hazard. Mater. 2019, 380, 120885. 7, , , , , , , Sci.
Cellular Membrane‐Engineered Nanovesicles as a Three‐Stage Booster to Target the Lesion Core
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202302801-sup-0001-SuppMat.pdf2.6 MB Supporting Information References 1, , , , , , , , , Brain 2021, 144, 144. 2, , , , , , , , , , , Signal Transduction TargetedTher. 2022, 7, 184. 3, , , Nat. Immunol. 2018, 19, 442. 4, , , , Neural Regener. Res. 2021, 16, 433. 5, , , , , , , , , , , , , , , , , , Brain 2021, 144, 3492. 6, , , , , , , , , Front. Neurosci. 2019, 13, 209. 7, , , Acta Biomater.
Sustainable Assessment Tools for Higher Education Institutions: Developing Two-Hierarchy Tools for China
1. Introduction The global commitment to sustainability is attracting increasing attention [], and strong commitments are needed for countries to take action to create a shared sustainable future. In the context of education, sustainability in education refers to programs that aim to protect the environment and promote the responsible use of natural resources [,].
Development of tissue-engineered tracheal scaffold with refined mechanical properties and vascularisation for tracheal regeneration
1 Introduction Replacement of large tracheal defects is a complex issue, with little clinical success to date in spite of other advancements in modern medicine. Two key issues facing tracheal replacement are 1) the mechanical differences between the implant and surrounding native tissue and 2) of host acceptance of implants and integration into the host vascular network.
Physical Processing for Decellularized Nerve Xenograft in Peripheral Nerve Regeneration
Ming-Wei Hsu1, Szu-Han Chen1,2,3, Wan-Ling Tseng4, Kuo-Shu Hung1, Tzu-Chun Chung5, Sheng-Che Lin6, Jahyun Koo7 and Yuan-Yu Hsueh1,2,3* 1Division of Plastic and Reconstructive Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan 2Center of Cell Therapy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan 3International Research Center for Wound Repair...
Regulating Type H Vessel Formation and Bone Metabolism via Bone‐Targeting Oral Micro/Nano‐Hydrogel Microspheres to Prevent Bone Loss (Adv. Sci. 15/2023)
Graphical Abstract Osteoporosis A pH-responsive shell-core structured micro/nano-hydrogel microspheres construct via gas microfluidics and ionic cross-linking technique. The microspheres can achieve oral delivery, intragastric protection, intestinal slow/controlled release, and active targeting to bone tissue. This novel oral microspheres can simultaneously accelerate intraosseous vascularization and decrease bone resorption, offering a brand-new approach to prevent postmenopausal osteoporosis.
Molecules | Free Full-Text | Fabrication, Facilitating Gas Permeability, and Molecular Simulations of Porous Hypercrosslinked Polymers Embedding 6FDA-Based Polyimide Mixed-Matrix Membranes
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Oral Administration of Multistage Albumin Nanomedicine Depots (MANDs) for Targeted Efficient Alleviation of Chronic Inflammatory Diseases
Abstract Methotrexate (MTX) by oral taking has been employed as the first-line medication for various chronic inflammatory diseases treatment, such as Crohn's disease and rheumatoid arthritis (RA). However, the oral administration of MTX has very limited clinical benefits and will be discontinued due to the suboptimal response and severe adverse effects on intestinal mucosa.
Improved Antitumor Activity of Novel Redox-Responsive Paclitaxel-Encapsulated Liposomes Based on Disulfide Phosphatidylcholine
The microtubule inhibitor paclitaxel (PTX) is used to treat a wide range of solid tumors. Due to the poor aqueous solubility of PTX, a continuous demand for safe, efficient PTX formulations with improved antitumor activity exists. Here, we report a novel form of redox-sensitive paclitaxel (PTX)-encapsulated liposomes based on the previously developed disulfide phosphatidylcholine (SS-PC).
Redox-sensitive dimeric camptothecin phosphatidylcholines-based liposomes for improved anticancer efficacy
Information © 2019 Future Medicine Ltd KeywordsSupplementary data To view the supplementary data that accompany this paper please visit the journal website at: www.futuremedicine.com/doi/suppl/10.2217/nnm-2019-0261 Financial & competing interests disclosure This work was supported by the National Major Science and Technology Program of China for Innovative Drug under Grant (2017ZX09101002-001-004).
Disulfide Phosphatidylcholines: Alternative Phospholipids for the Preparation of Functional Liposomes
Disulfide Phosphatidylcholines: Alternative Phospholipids for the Preparation of Functional Liposomes Phosphatidylcholine is the main component of liposomes and other phospholipid-based nanoassemblies used as nanocarriers in drug delivery. However, the functions and applications of these nanocarriers are extremely limited by the conventional phospholipids.
High Drug Loading, Reversible Disulfide Core-Cross-Linked Multifunctional Micelles for Triggered Release of Camptothecin
Nanomedicines in polymeric therapeutics present a potential treatment for cancers. However, their clinical effectiveness still has room to be improved. Herein, reduction-responsive reversibly core-cross-linked micelles based on the poly(ethylene glycol)-dihydrolipoic acid (MeO-PEG -DHLA) conjugate were developed for triggered intracellular release of camptothecin (CPT).
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