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ArticleVolume 45, Issue 7117664Open access Affiliations & Notes 1Division of Biological Sciences, University of California, La Jolla, San Diego, CA, USA 2Department of Pediatrics, University of California, San Diego, San Diego School of Medicine, La Jolla, San Diego, CA, USA 3Infectious Disease and Microbiome Program, The Broad Institute, Cambridge, MA, USA 4Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA 5Department of Microbiology...
This text is not any kind of speech in favor of any technological regression or an ode to the past, but rather, my analysis of how the digitization of our daily lives has been pushing me further away from the digital and closer to the analog.
Abstract Malaria poses an enormous threat to human health. With ever increasing resistance to currently deployed drugs, breakthrough compounds with novel mechanisms of action are urgently needed. Here, we explore pyrimidine-based sulfonamides as a new low molecular weight inhibitor class with drug-like physical parameters and a synthetically accessible scaffold.
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