Yiling Li
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Articles by Yiling Li
PediatricLiver score: a novel risk score for screening elevated liver stiffness in the pediatric population (CHESS2401)
Abstract Given the looming crisis of rapid increase in childhood obesity globally, chronic metabolic diseases have consequently emerged but without sufficient awareness among children. Reliable and accessible screening tools thus are required to screen for significant liver fibrosis in the general pediatric population. This prospective cohort study comprised three independent cohorts: a training cohort, and two validation cohorts from China and the USA, respectively.
Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound-Derived LIID and LSM in MASLD: A Multicenter Study
ALT alanine aminotransferase AST aspartate aminotransferase BMI body mass index CI confidence interval GGT γ-glutamyltranspeptidase HDL-C high-density lipoprotein cholesterol HOMA-IR homeostasis model assessment of insulin resistance LDL-C low-density lipoprotein cholesterol LSM liver stiffness measurement MASH metabolic dysfunction-associated steatohepatitis MASLD metabolic dysfunction-associated steatotic liver disease NAFLD nonalcoholic fatty liver disease NAS NAFLD activity score NAS-CRN...
Ultralow-Dose Interleukin 10–Expressing Chimeric Antigen Receptor T Cells in Relapsed/Refractory Diffuse Large B-Cell Lymphoma : A Nonrandomized Clinical Trial
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Ultralow-Dose Interleukin 10–Expressing Chimeric Antigen Receptor T Cells in Relapsed/Refractory Diffuse Large B-Cell Lymphoma: A Nonrandomized Clinical Trial Key Points Question What is the safety and efficacy of interleukin 10–expressing CD19 chimeric antigen receptor (CAR) T cells (META 10-19) in adults with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL)?
By Yongxian Hu, Mingming Zhang, Min Gao, Shan Fu, Yiling Li, Jingjing Feng, Ruimin Hong, Guoqing Wei, Duoduo Zhao, Jiazhen Cui, Simao Huang, Jingjing Ren, Youjia Li, Qian Chen, Zhan Zhou, Dongrui Wang, Yugang Guo, Li Tang, Xingbing Wang, He Huang, Yetian Dong, Xunuo Zhu, Daojun Bai, Baoyun Cheng, Yuanbin Cui, Chongling Liu
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JAMA Oncology
Verified
Mathematics > Numerical Analysis
This paper concerns the inverse elastic scattering problem of determining an unknown penetrable obstacle from far-field data. Using the Helmholtz decomposition, the coupled boundary value problem is reformulated as a coupled scalar Helmholtz system. We prove the uniqueness of the associated coupled Helmholtz boundary value problem and of the corresponding boundary integral equation system, which is then discretized by a Nyström method for efficient numerical computation.
Transcriptional repression by TGIF2 coordinates neurogenic priming and neural stem cell maintenance
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Stem cells balance self-renewal with differentiation. Priming, i.e., low-level expression of differentiation-related genes, enables stem cells to remain undifferentiated and progeny to fast proceed in up-regulation of differentiation genes.
Nuclear proteome reveals microtubule-associated protein regulating fate and disease
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Keywords neural stem cells neurogenesis migration cell fate periventricular heterotopia cortical malformations organoids MAP1B moonlighting proteins brain development Introduction Tissue development relies fundamentally on morphogenesis, regulated by the dynamic remodeling of the cytoskeleton as well as transcriptional programs driving cell fate and subtype specification.
By Florencia L. Merino, Lucas Miranda, Aparajita Kumar, Yiling Li, Deepak Kumar Sundaramoorthy, Juliane Merl-Pham, Eva-Maria Schentarra, Clemens Steinek, Veronica Pravatá, Claire M. Kittock, Martina Bürkle, Bob A. Hersbach, Javier Ferri Beneito, Florian Giesert, Ralf Jungmann, Louis-Jan Pilaz, Stefanie Hauck, Silvia Cappello, Magdalena Götz
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Cell Press
Verified
Nuclear proteome reveals microtubule-associated protein regulating fate and disease
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Keywords neural stem cells neurogenesis migration cell fate periventricular heterotopia cortical malformations organoids MAP1B moonlighting proteins brain development Introduction Tissue development relies fundamentally on morphogenesis, regulated by the dynamic remodeling of the cytoskeleton as well as transcriptional programs driving cell fate and subtype specification.
By Florencia L. Merino, Lucas Miranda, Aparajita Kumar, Yiling Li, Deepak Kumar Sundaramoorthy, Juliane Merl-Pham, Eva-Maria Schentarra, Clemens Steinek, Veronica Pravatá, Claire M. Kittock, Martina Bürkle, Bob A. Hersbach, Javier Ferri Beneito, Florian Giesert, Ralf Jungmann, Louis-Jan Pilaz, Stefanie Hauck, Silvia Cappello, Magdalena Götz
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Cell Press
Verified
Spatial transcriptomics defines IM-crypt as a premalignant niche with bidirectional divergence in early gastric carcinogenesis
Abstract Early gastric carcinogenesis progresses from gastritis through intestinal metaplasia to early gastric cancer, yet the spatial origin of malignant transformation and subtype divergence remains unclear.
Tu1206 EFFICACY AND SAFETY OF HIGH-DOSE ILAPRAZOLE DUAL THERAPY FOR HELICOBACTER PYLORI ERADICATION: A MULTICENTER, OPEN-LABEL, RANDOMIZED CONTROL STUDY IN CHINA
Also available on ScienceDirect
Heteromorphic XY chromosomes with pericentromeric recombination suppression in Hippophae (Elaeagnaceae)
Fig. S1 Features of the anchored assemblies of haplotype-resolved genomes for two Hippophae species. Fig. S2 Transposable elements and tandem repeats of Hippophae rhamnoides (Hrh-hapA, containing the X) and Hippophae tibetana (Hti-hapA, containing the X) haplotype genomes. Fig. S3 Collinear analysis among the three species. Fig. S4 Structural variation regions and Hi-C interaction heatmap between haplotypes in chromosome 1 of Hippophae rhamnoides and Hippophae tibetana. Fig.
The evolution of sexually dimorphic expression in Salicaceae with repeated sex chromosome turnovers
Conflicts of Interest The authors declare no conflict of interest. Data Availability Statement All raw sequence data have been deposited in the National Genome Data Center (NGDC; https://bigd.big.ac.cn/bioproject) under BioProject accession number PRJCA024542. The supplementary data are available in the Science Data Bank (https://doi.org/10.57760/sciencedb.35245).
A new two-gene system of sex determination in a Salicaceae
Keywords sex chromosomes sex-determining region centromeres XY system unisexual flower development haplotype-resolved genome Introduction The genetic bases of angiosperm sex-determining systems are currently understood in barely two dozen species (Figure 1A), yet angiosperms comprise between 871 and 5,000 independent origins of dioecy.1,2 With this sparse sampling, generalizations are risky, because sex determination of dioecious flowering plants may involve many genes, given that male or...
Correction to “Protein-Binding Patterns Drive the Transport of Mercury in Plasma and Red Blood Cells in Rats”
In the originally published version of this article, panels c–f of Figure 2 contained an inadvertent graphical error introduced during layout adjustment at the revision stage. During efforts to improve the visual balance of the figure, the Y-axis was temporarily repositioned horizontally, and a handling error occurred that reversed the channel orientation, resulting in a switched representation between data channels.
Status Quo and Real Experience of Missed Nursing Care in ICUs: A Scoping Review
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Data sharing not applicable to this article as no datasets were generated or analysed during the current study. Supporting Information Filename Description nicc70243-sup-0001-Supinfo.docxWord 2007 document , 91.2 KB Appendix S1: PRISMA-ScR-fillable-checklist.
Electrospun Poly(lactic-co-glycolic acid) Nanofiber Scaffolds Functionalized by Aggregation-Induced Emission Luminogens for Second Near-Infrared Imaging-Guided Photothermal Therapy of Residual Tumors
Introduction Click to copy section linkSection link copied! Cancer, particularly solid tumors, has emerged as a significant global health risk. Currently, surgery remains the main treatment method for solid tumors. Achieving a complete (R0) resection is a critical objective in the treatment of numerous solid tumors, which can substantially influence patient prognosis.
Electrospun Poly(lactic-co-glycolic acid) Nanofiber Scaffolds Functionalized by Aggregation-Induced Emission Luminogens for Second Near-Infrared Imaging-Guided Photothermal Therapy of Residual Tumors
ACS Applied Materials & Interfaces Cite this: ACS Appl. Mater. Interfaces 2025, XXXX, XXX Click to copy citationCitation copied! . This publication is licensed under CC-BY-NC-ND 4.0 . You are free to share (copy and redistribute) this article in any medium or format within the parameters below: Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. Non-Commercial (NC): Only non-commercial uses of the work are permitted.
Plasmon-enhanced ultralow-threshold solid-state triplet fusion upconversion - Nature Photonics
Abstract Triplet fusion upconversion has potential applications in solar cells, photoredox catalysis, additive manufacturing and bioimaging. However, solid-state upconversion systems have struggled to measure up to their solution-phase counterparts, often requiring enormous optical power densities to operate at the maximum efficiency.
Ancient allopolyploidy and specific subgenomic evolution drove the radiation of poplars and willows - Nature Communications
Abstract Allopolyploidy involves the fusion of genomes from different lineages through hybridization and chromosome doubling. However, detecting early allopolyploidy events and understanding the specific subgenomic evolution that contributes to the origin of adaptive innovations for species radiation can be challenging. Here, we present genomes representing all three subfamilies of Salicaceae, a woody model clade, and collect epigenetic and transcriptomic samples.
Reflections on the methodological validity and clinical applicability of weight loss‐induced uric acid reduction
Letter Reflections on the methodological validity and clinical applicability of weight loss-induced uric acid reduction Reply Arthritis & Rheumatology First Published online: July 24, 2025 First published: 18 June 2025 No abstract is available for this article. Filename Description art43292-sup-0001-Disclosureform.pdfPDF document, 98.1 KB Disclosure form. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors.
Synergies of MYC Inhibition with Photothermal, Photodynamic, and Radio
Back to Journals » International Journal of Nanomedicine » Volume 20 Authors Cui Y, Yang W, Liu W, Li Y, Yu C, Yu C, Liu Y , Xu D, Zhu X Received 6 March 2025 Accepted for publication 18 September 2025 Published 11 October 2025 Volume 2025:20 Pages 12413—12430 DOI https://doi.org/10.2147/IJN.S526592 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Sachin Mali Yingwen Cui,1,* Wanhong Yang,1,2,* Wuyan Liu,1,3...
TGIF2 is a major regulator of neural stem cell fate and neurogenic priming
Abstract During brain development, neural stem cells (NSCs) must balance self-renewal with differentiation and ensure lineage progression. To identify novel regulators of NSCs during neurogenesis, we isolated NSCs by FACS from the mouse cerebral cortex and ganglionic eminence at mid-neurogenesis, and at birth, when gliogenesis starts in both, but neurogenesis only continues in the latter region.
A Study of the Capacitated Vehicle Routing Problem with Time-Window and Three-Dimensional Loading Constraints in Land-Sea Transport
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
CD63 + tumor-associated macrophages drive the progression of hepatocellular carcinoma through the induction of epithelial-mesenchymal transition and lipid reprogramming | BMC Cancer | Full Text
In total, 104,428 cells passed the quality control standards for inclusion in this analysis, of which the NIH and BRPC cohorts respectively contributed 43,011 and 61,417 cells. HCV-related HCC samples comprised the greatest proportion (42.86%) of the scRNA-seq data, whereas HBV-related HCC and nonviral-related HCC samples each comprised 28.57% of these data.
Construction and Validation of a Rat Model of Acute Necrotizing Pancreatitis-Associated Intestinal Injury
Acute pancreatitis (AP) is an acute inflammatory reaction of the pancreatic tissue, which involves auto-digestion, oedema, haemorrhage, and necrosis. AP can be categorized into mild, moderately severe and severe AP, with severe pancreatitis also referred to as acute necrotizing pancreatitis (ANP). ANP is characterized by the accumulation of necrotic material in the peritoneal cavity. This can result in intestinal injury. However, the mechanism of ANP-associated intestinal injury remains unclear.
Response to: “Merit of integrating in situ transcriptomics and anatomical information for cell annotation and lineage construction in single-cell analyses of Populus” | Genome Biology | Full Text
References Chen YL, Hsieh JW, Kuo SC, Kao CT, Tung CC, Yu JH, Chang TH, Ku C, Xie J, Zhang D, Li Q, Lin YJ. Merit of integrating in situ transcriptomics and anatomical information for cell annotation and lineage construction in single-cell analyses of Populus. Genome Biol. 2024. https://doi.org/10.1186/s13059-024-03227-5. Article PubMed PubMed Central Google Scholar Li H, Dai X, Huang X, Xu M, Wang Q, Yan X, Sederoff RR, Li Q, et al.
Design, Synthesis, and Biological Application of A-D-A Type Boranil Fluorescent Dyes
Design, Synthesis, and Biological Application of A-D-A Type Boranil Fluorescent Dyes For the first time, three acceptor-donor-acceptor (A-D-A) type Boranil fluorescent dyes, CSU-BF-R (R = H, CH3, OCH3), featuring phenothiazine as the donor, were designed and synthesized. CSU-BF-R exhibited remarkable photophysical characteristics, including large Stokes shifts (>150 nm), high fluorescence quantum yields (up to 40%), long-wavelength emissions, and strong red solid-state fluorescence.
Tumor Microenvironment-Activatable Phototheranostic: Leveraging Nitric Oxide and Weak Acidity as Dual Biomarkers for Ratiometric Fluorescence, Photoacoustic Imaging, and Photothermal Therapy
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
The Identification and Role of the Key Mycotoxin of Pestalotiopsis kenyana Causing Leaf Spot Disease of Zanthoxylum schinifolium
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Carbon Monoxide: A Second Biomarker to Couple with Viscosity for the Construction of “Dual-Locked” Near-Infrared Fluorescent Probes for Accurately Diagnosing Non-Alcoholic Fatty Liver Disease
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
SimcereZaiming showcases latest R&D progressed on its debut at ASCO， as 6 studies regarding 3 products published at ASCO
Bijoyesh Mookerjee，M.D., CMO of Simcere Zaiming（left 4）held pleasant conversation with visitors at Zaiming’s booth Zaiming showcased the company’s innovative R&D pipeline at ASCO Booth Simcere Zaiming, an innovative oncology-focused biopharma and a subsidiary of Simcere Pharmaceutical Group, exhibited a booth at ASCO for the first time.
SPSQL: Step-by-step Parsing Based Framework for Text-to-SQL Generation
arXiv:2305.11061 (cs) Download a PDF of the paper titled SPSQL: Step-by-step Parsing Based Framework for Text-to-SQL Generation, by Ran Shen and 4 other authors Download PDF Submission history From: Han Jiang [ view email] [v1] Wed, 10 May 2023 10:01:36 UTC (1,088 KB) Bibliographic Tools Bibliographic Explorer Toggle Bibliographic Explorer () Litmaps Toggle Litmaps (What is Litmaps?) scite.ai Toggle scite Smart Citations (What are Smart Citations?) Code, Data, Media DagsHub Toggle DagsHub...
HNRNPA2B1-Mediated MicroRNA-92a Upregulation and Section Acts as a Promising Noninvasive Diagnostic Biomarker in Colorectal Cancer
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Characterization of mercury-binding proteins in rat blood plasma
Y. Li, B. He, Q. Nong, G. Qu, L. Liu, J. Shi, L. Hu and G. Jiang, Chem. Commun., 2018, 54, 7439 DOI: 10.1039/C8CC02144A If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.
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