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Yiming Yin

As seen in: Nature, MDPI, ACS Publications, BioRxiv, Cell Press, Canadian Journal of Infectious Diseases & Medical Microbiology, Dove Medical Press, The Journal of Clinical Investigation, The Journal of Immunology
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Articles

SGLT2 inhibitors enhance ketogenesis by acting as allosteric activators of the mitochondrial enzyme HMGCS2

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By Abdualrahman Mohammed Abdualkader, Xiaobei Li, Yiming Yin
| The Journal of Clinical Investigation
To the Editor: The discovery of sodium-glucose cotransporter-2 inhibitors (SGLT2i) has transformed the management of type 2 diabetes, cardiovascular disease, and kidney disease. SGLT2i reduce cardiovascular death, heart failure hospitalizations, and kidney failure progression in patients with or without diabetes (1), indicating benefits beyond glucose lowering. Emerging evidence suggests these cardiorenal benefits are partly mediated by increases in plasma ketone bodies (2).
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Development and Validation of a Machine Learning Model for Predicting | NDT

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By Yixin Liang, Yiming Yin, Kun Zhen
| Dove Medical Press
Back to Journals » Neuropsychiatric Disease and Treatment » Volume 22 Authors Liang Y, Yin Y, Zhen K , Lin H, Yu G , Li X Received 10 December 2025 Accepted for publication 30 January 2026 Published 17 February 2026 Volume 2026:22 Pages 1—12 DOI https://doi.org/10.2147/NDT.S582787 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 4 Editor who approved publication: Professor Taro Kishi Yixin Liang,1 Yiming Yin,2 Kun Zhen,3 Hongxiao Lin,4 Guran Yu,1 Xin...
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In vivo affinity maturation of the CD4 domains of an HIV-1-entry inhibitor - Nature Biomedical Engineering

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By Tianling Ou, Yiming Yin, Michael Farzan
| Nature Verified
Abstract Human proteins repurposed as biologics for clinical use have been engineered through in vitro techniques that improve the affinity of the biologics for their ligands. However, the techniques do not select against properties, such as protease sensitivity or self-reactivity, that impair the biologics’ clinical efficacy.
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