Ying C. Henderson
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TERT Promoter Variants, Older Age, and Prognosis in Papillary Thyroid Carcinoma
TERT Promoter Variants, Older Age, and Prognosis in Papillary Thyroid Carcinoma Key Points Question Is the association between older age and poor prognosis in papillary thyroid carcinoma explained by TERT promoter variants? Findings In this multi-institutional cohort study of 1555 patients with papillary thyroid carcinoma, the prevalence of TERT promoter variants increased progressively with age and was independently associated with higher disease-specific mortality.
"Anaplastic Transformation in Thyroid Cancer Revealed by Single-Cell Tr" by Lina Lu, Jennifer Rui Wang et al.
Abstract The deadliest anaplastic thyroid cancer (ATC) often transforms from indolent differentiated thyroid cancer (DTC); however, the complex intratumor transformation process is poorly understood. We investigated an anaplastic transformation model by dissecting both cell lineage and cell fate transitions using single-cell transcriptomic and genetic alteration data from patients with different subtypes of thyroid cancer.
Anaplastic transformation in thyroid cancer revealed by single cell transcriptomics
ResearchIn-Press PreviewGeneticsOncology Open Access | 10.1172/JCI169653 J Clin Invest. https://doi.org/10.1172/JCI169653. Copyright © 2023, Lu et al. This work is licensed under the Creative Commons Attribution 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
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