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CLEC-2 C-type lectin-like receptor 2 CRP-XL cross-linked collagen-related peptide GPVI glycoprotein VI HDLECs human dermal lymphatic endothelial cells MAS9 ethyl 1-[(8-hydroxy-5-quinolinyl)methyl]-3-piperidinecarboxylate What is already known The CLEC-2–podoplanin interaction is a promising target for development of antiplatelet drugs against thrombo-inflammation. Existing small molecule inhibitors exhibit limitations in terms of potency, toxicity or specificity.

Keywords proteomics systems virology virus signaling Sendai virus CRTC interleukin-11 Research topic(s) CP: Microbiology CP: Cell biology Introduction Subcellular relocation of cellular sensors and their signaling components forms a crucial first step in the recognition of any intracellular pathogen and determines the outcome of infection by orchestrating effective antiviral immunity.

Introduction Acute pancreatitis is a disease characterized by the activation of pancreatic enzymes due to various causes, resulting in local or systemic inflammatory reactions in the pancreas, with or without associated organ dysfunction.1 Acute necrotizing pancreatitis(ANP) is a more severe form, defined as pancreatic parenchymal necrosis with or without involvement of surrounding tissues, and is associated with a high morbidity and mortality rate.2,3 Paroxysmal nocturnal hemoglobinuria(PNH)...