Ying Huo

Abstract Tubulointerstitial fibrosis (TIF) is a crucial pathological feature and inevitable consequence of progressive diabetic kidney disease (DKD). Transfer RNA-derived fragments (tRFs), a novel class of small non-coding RNA by cleavage of tRNAs, have recently attracted attention due to their functional significance in diverse biological processes. However, the role of tRFs in TIF is largely elusive.

Abstract Triple-negative breast cancer (TNBC) exhibits iron homeostasis that supports tumor growth and proliferation, yet the regulatory mechanisms controlling iron flux remain poorly defined. Here, we identify a ferritinophagic cargo receptor NCOA4 as a novel substrate of the lysine methyltransferase SUV39H2, uncovering a previously unrecognized mechanism that regulates ferritinophagy and ferroptosis.

Conflicts of Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. Supporting Information Filename Description biot70110-sup-0001-SupMat.docx2.1 MB Supporting File: biot70110-sup-0001-SupMat.docx. References 1, , , , and , “Effect of Growth Regulators on Yield and Fiber Quality in Ramie (Boemheria nivea (L.) Gaud.), China Grass,” Field Crops Research 69 (2001): 41–46.