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Ying-Nai Wang on Muck Rack

Ying-Nai Wang

As seen in: Nature, Journal of Biomedical Science, Cell Press, Texas Medical Center
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Articles

All-trans retinoic acid destabilizes ADAR1 protein through retinoylation-mediated USP7 dissociation and improves immunotherapy in pancreatic cancer

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By Ching-Fei Li, Yongkun Wei, Heng-Huan Lee, Wei-Chao Chang, Yun Xiong, Yitao Tang, Riyao Yang, Jun Yao, Huamin Wang, Xiaofei Wang, Minghui Liu, Jangho Park, Jie Fu, Ying-Nai Wang, Li-Yuan Bai, Shao-Chun Wang, Jianhua Ling, Yu-Yi Chu, Zhenzhen Xun, Anirban Maitra, Wantong Yao, Dihua Yu, Paul Chiao, Haoqiang Ying, Mien-Chie Hung, Cheng-Wei Chou
| Nature Verified
Abstract Adenosine deaminase acting on RNA 1 (ADAR1) contributes to immunotherapy resistance by suppressing interferon signaling. Therapeutic targeting of ADAR1 has not been achieved to date in clinical settings. Here, we discover all-trans retinoic acid (ATRA) promotes ADAR1 protein degradation in cancer. In addition, ATRA induces PD-L1 and combination of ATRA and PD-1 blockade reprograms tumor microenvironments to unleash antitumor immunity, thereby impeding tumor growth.
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"Ribonuclease 1 Enhances Antitumor Immunity Against Breast Cancer by Bo" by Ying-Nai Wang, Heng-Huan Lee et al.

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By Ying-Nai Wang, Heng-Huan Lee, Zhou Jiang, Li-Chuan Chan
| Texas Medical Center
Abstract The secretory enzyme human ribonuclease 1 (RNase1) is involved in innate immunity and anti-inflammation, achieving host defense and anti-cancer effects; however, whether RNase1 contributes to adaptive immune response in the tumor microenvironment (TME) remains unclear. Here, we established a syngeneic immunocompetent mouse model in breast cancer and demonstrated that ectopic RNase1 expression significantly inhibited tumor progression.
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Nuclear Export Signal Mutation of Epidermal Growth Factor Receptor Enhances Malignant Phenotypes of Cancer Cells

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By Lei Nie, Ying-Nai Wang, Jung-Mao Hsu, Junwei Hou
| Texas Medical Center
Home > UTHealth > GSBS > Journal Articles > 463 American Journal of Cancer Resarch EGFR, nuclear translocation, activating mutations, NES, NLS, CRM1, exportin, internalization, non-small cell lung cancer DOWNLOADS Included in Bioinformatics Commons, Biological Phenomena, Cell Phenomena, and Immunity Commons, Biomedical Informatics Commons, Oncology Commons, Pulmonology Commons COinS
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