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Ying Wan

As seen in: Nature, Wiley Online Library, MDPI, ACS Publications, Biomed Central (BMC), JAMA Network, Virology Journal, Royal Society of Chemistry, Cell Reports, Canadian Journal of Infectious Diseases & Medical Microbiology and
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Articles

State-dependent reconfiguration failure of the basal forebrain-cortical gradient in Parkinson’s disease with freezing of gait

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By Chen Liu, Zhao Jiahao, Lu Song, Ying Wan, Na Wu, Xinxin CHEN, Yu Zhang, Chen Qi, Bingjie Ma, Zhihua Liu, Gaiying Li, Jianqi Li, Xi Wu, Zhenguo Liu, Jing Gan, Hou Miaomiao
| Nature Verified
Abstract Accumulating evidence implicates cholinergic dysfunction in freezing of gait (FOG) in Parkinson’s disease (PD). Given the basal forebrain (BF) provides the primary cholinergic input to the cortex, elucidating BF-cortical connectivity and its dynamic reconfiguration during motor challenges in PD-FOG is important. This study included 44 PD-FOG, 45 without FOG (PD-NFOG), and 27 healthy controls (HC). All underwent diffusion and resting-state functional MRI.
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A highly efficient detection model for early-stage Parkinson’s disease using non-contact, multi-modality measurement and artificial intelligence

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By Ying Wan, Xiaoyue Wan, Zhuoran Liu, Yuwen Zhao, Yuheng Chen, Lu Rong, Shuili Yu, Jing Gan, Yuxin Li, Lin Li, Zixuan Zhao, Chen Qi, Na Wu, Lu Song, Yu Zhang, Wei Chen, Zhenguo Liu, Xu Zhao, Bingzhi Duan
| Nature Verified
Abstract Early diagnosis of Parkinson’s disease (PD) is challenging due to the difficulty in identification of various early motor signs. We aimed to develop and validate a highly efficient detection model for early-stage PD using an optimal modality (OM) selection strategy. 151 off-medication, early-stage PD patients and 138 controls were divided into a development cohort and a validation cohort at 5:1 ratio.
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Intermittent Theta-Burst Stimulation for Depressive Symptoms in Parkinson Disease : A Randomized Clinical Trial

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By Miaomiao Hou, Bingjie Tian, Chen Qi, Lu Song, Bingjie Ma, Xinxin CHEN, Ying Wan, Na Wu, Jing Gan, Zhenguo Liu, Yu ZHANG
| JAMA Network Verified
Supplement 1. Trial Protocol and Statistical Analysis Plan Supplement 2. eTable 1. MNI Coordinates for All Channels and Corresponding Brodmann Area Mappings eTable 2. Raw Data of Primary and Secondary Outcomes eTable 3. Summary Statistics and Results From Mixed Model Analysis of Change in Outcomes From Baseline, by Visit eTable 4. Sensitivity Analysis of the Primary End Point: Changes in HAMD-24 From Baseline to Week 6 eTable 5. Statistics of AUC of HbO in the DLPFC-L, FPA-L and FEF-L eFigure 2.
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