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Articles by Ying Wan
A novel ferro-aging-related gene signature for prognosis and targeted drug prediction in cervical cancer
Abstract Cervical cancer (CESC) remains a leading cause of cancer-related mortality in women. Recent studies have identified ferro-aging as a genuine biological pathway in primates, representing an iron-dependent metabolic process. However, cellular ageing and the decline in overall physiological function play a crucial role in tumour progression. Based on this, we have established a prognostic model related to ferro-aging and evaluated its predictive and diagnostic value in cervical cancer.
Exploring the association between oral fluency and communicative adequacy in task-based peer interactions among CSL learners
Abstract Understanding the relationship between oral fluency and communicative adequacy (CA) in second language acquisition is critical for effective pedagogical practices. This study aims to examine how oral fluency measures correlate with CA in task-based peer interactions among learners of Chinese as a second language (CSL), and to explore how different task types mediate this relationship. Data were collected from CSL learners performing storytelling and opinion-sharing tasks.
Aberrant brain functional connectivity in patients with dysthyroid optic neuropathy: a resting-state fMRI study
Abstract Objectives: We aimed to investigate the alterations of static and dynamic brain functional connectivity in dysthyroid optic neuropathy (DON) using resting-state functional MRI (rs-fMRI) with the voxel-mirrored homotopic connectivity (VMHC) and degree centrality (DC) methods. Materials and methods: Seventy-five thyroid-associated ophthalmopathy (TAO) patients (29 DON and 46 non-DON) and 32 healthy controls (HCs) were prospectively recruited.
A global framework for artificial intelligence education in medicine: international working group recommendations
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Abstract AI education in medicine remains fragmented, narrowly technical, and disconnected from healthcare realities. Through an international collaboration, we developed a framework spanning seven domains and 24 learning objectives. We reflect on what this process revealed: effective AI education must be clinically grounded, ethically integrated, and implementation-aware across the training continuum.
By Laura Rosella, Yindalon Aphinyanaphongs, James S. Barry, Orest Boyko, Harvey Castro, Anthony Chang, Shane L. Eaton, Bradley Erickson, Jamie Fairclough, Diana Ferro, Gregg M. Gascon, Nihal Haque, Robert Hoyt, Johanna Inhyang Kim, Pietro Liò, Muhammad Mamdani, Piyush Mathur, Ryan M. McAdams, Ehsan Misaghi, Abhishek Moturu, Oded Nov, Gemma Postill, Ying Wan, Nathan Yung, Alfonso Limon, Hari Mudipalli, Arwa Nada, Mijanou Pham, Zoryana Salo, Marianne So
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Nature
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Tuning electron back-donation to switch reaction pathway in CO 2 hydrogenation
Abstract CO2 hydrogenation over earth-abundant Ni catalysts is attractive for CO-based fuel synthesis, but Ni intrinsically favors methanation. Here we show that ordered Ni3Sn2 intermetallics tune Ni–CO electron back-donation and switch CO2 hydrogenation from CH4 formation to the reverse water–gas shift reaction.
State-dependent reconfiguration failure of the basal forebrain-cortical gradient in Parkinson’s disease with freezing of gait
Abstract Accumulating evidence implicates cholinergic dysfunction in freezing of gait (FOG) in Parkinson’s disease (PD). Given the basal forebrain (BF) provides the primary cholinergic input to the cortex, elucidating BF-cortical connectivity and its dynamic reconfiguration during motor challenges in PD-FOG is important. This study included 44 PD-FOG, 45 without FOG (PD-NFOG), and 27 healthy controls (HC). All underwent diffusion and resting-state functional MRI.
A highly efficient detection model for early-stage Parkinson’s disease using non-contact, multi-modality measurement and artificial intelligence
Abstract Early diagnosis of Parkinson’s disease (PD) is challenging due to the difficulty in identification of various early motor signs. We aimed to develop and validate a highly efficient detection model for early-stage PD using an optimal modality (OM) selection strategy. 151 off-medication, early-stage PD patients and 138 controls were divided into a development cohort and a validation cohort at 5:1 ratio.
Intermittent Theta-Burst Stimulation for Depressive Symptoms in Parkinson Disease : A Randomized Clinical Trial
Supplement 1. Trial Protocol and Statistical Analysis Plan Supplement 2. eTable 1. MNI Coordinates for All Channels and Corresponding Brodmann Area Mappings eTable 2. Raw Data of Primary and Secondary Outcomes eTable 3. Summary Statistics and Results From Mixed Model Analysis of Change in Outcomes From Baseline, by Visit eTable 4. Sensitivity Analysis of the Primary End Point: Changes in HAMD-24 From Baseline to Week 6 eTable 5. Statistics of AUC of HbO in the DLPFC-L, FPA-L and FEF-L eFigure 2.
In vivo generation of anti-BCMA CAR-T cells in relapsed or refractory multiple myeloma: a phase 1 study
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Abstract In vivo chimeric antigen receptor (CAR)-T cell generation can bypass ex vivo manufacturing and lymphodepletion, potentially simplifying and accelerating access to cellular therapy; preliminary clinical experience supports feasibility and suggests preliminary efficacy.
By Ning An, Di Wang, Peiling Zhang, Jishuai Zhang, Philippe Parone, Jianlin Hu, Yuhan Bao, Li Xu, Ying Wan, Xinyu Wen, Yang Gao Verified, Chunrui Li, Haitao Ruan
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Nature
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Comparative Analysis of T‐Cell and Bone Marrow Chimerism for Relapse Prediction in Acute Leukaemia Post‐Transplantation
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. Supporting Information Filename Description tan70588-sup-0001-FigureS1.pdfPDF document, 382.5 KB Figure S1: The receiver operating curves (ROC) for the T-Cell chimerism and BM chimerism analyses. (A) ROC for BM chimerism rate. (B) ROC for T-cell chimerism rate. AUC, area-under-the-curve.
No Effect of Immunogenicity on Pharmacokinetics, Efficacy, and Safety of the Oligonucleotide Telomerase Inhibitor Imetelstat in Lower‐Risk Myelodysplastic Syndromes
1 Introduction Imetelstat (GRN163L; RYTELO) is a novel, first-in-class, 13-mer N3′ → P5′ thio-phosphoramidate oligonucleotide with a covalently attached palmitoyl lipid group [1, 2]. Imetelstat acts by binding with high affinity to the template region of the RNA component of human telomerase, which lies in the active or catalytic site of human telomerase reverse transcriptase (hTERT), resulting in competitive inhibition of hTERT enzymatic activity [1, 2].
Event‐triggered platooning control for heterogeneous vehicles under denial‐of‐service attacks and time delays: A topology recovery approach
CONFLICT OF INTEREST STATEMENT The authors declare that they have no conflict of interest. DATA AVAILABILITY STATEMENT Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study. REFERENCES 1, , and , Adaptive finite-time cooperative platoon control of connected vehicles under actuator saturation, Asian J. Control 24 (2022), no. 6, 3552–2565.
Retraction: An orange peel-derived zirconium-coordination polymer for highly efficient reductive upgradation of 5-hydroxymethylfurfural
Retraction: An orange peel-derived zirconium-coordination polymer for highly efficient reductive upgradation of 5-hydroxymethylfurfural Retraction of ‘An orange peel-derived zirconium-coordination polymer for highly efficient reductive upgradation of 5-hydroxymethylfurfural’ by Siyu Sun et al., New J. Chem., 2024, 48, 19661–19673, https://doi.org/10.1039/D4NJ03426K. This article is Open Access This article has not yet been cited.
Acidogenesis‐Propelled Coordination Transition in Light‐Triggered Fe‐Polyphenol Polymer for Reactive Oxygen Species‐Augmented Antitumor Therapy
1 Introduction Reactive oxygen species (ROS)-based tumor therapy strategies, which utilize exogenous or endogenous substances to catalyze oxidative reactions, inducing intracellular oxidative stress that causes irreversible damage to biomolecules and triggers cell apoptosis, have emerged as promising approaches for cancer treatment.[1, 2] These strategies mainly involve nanozymes with enzymatic-like activities, photodynamic therapy using light-activated photosensitizers and energy transfer to...
Hard Nodule on the Posterior Portion of the Tongue in a Young Patient
Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
A Comprehensive Analysis of Population Pharmacokinetic Models of Teico
Back to Journals » Infection and Drug Resistance » Volume 18 Authors Yu B , Wan Y, Ji W, Mao J , Zhang R, Shen Z, Hu Y, Cai H Received 27 June 2025 Accepted for publication 16 October 2025 Published 27 October 2025 Volume 2025:18 Pages 5529—5548 DOI https://doi.org/10.2147/IDR.S549854 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Dr Hemant Joshi Biao Yu,1,* Ying Wan,1,* Wenbo Ji,1 Juehui Mao,2 Runcong...
Population Pharmacokinetics and Covariate Analysis of Methotrexate in | DDDT
Back to Journals » Drug Design, Development and Therapy » Volume 19 Authors Yu B , Wan Y, Mei K, Zhan D, Tang Q, Hu X, Ji W, Cai H Received 7 June 2025 Accepted for publication 3 September 2025 Published 18 September 2025 Volume 2025:19 Pages 8475—8488 DOI https://doi.org/10.2147/DDDT.S545368 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Muzammal Hussain Biao Yu,* Ying Wan,* Kangkang Mei, Didi Zhan, Qi...
Tailored Design of Mesoporous Metal Organic Framework Single Crystals by Kinetics‐Mediated Micelle Assembly for Efficient Asymmetrical Single‐Atom Catalysis
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adma202500370-sup-0001-SuppMat.docx4.3 MB Supporting Information References 1, , , , , , , , , , , , Adv. Mater. 2024, 36, 2400523. 2, , , , , J. Am. Chem. Soc. 2022, 144, 18155. 3, , , , , , , , , , , Adv. Funct. Mater. 2022, 32, 2111446. 4, , , , , , , , , , , Angew. Chem., Int. Ed. 2021, 60, 27324. 5, , , , , , , , , , Angew. Chem., Int. Ed. 2022, 61, 202117617.
An Exploratory Analysis of Rhythmic Auditory Stimulation's Impact on Brain Function in Parkinson's Disease Patients With Freezing of Gait
1 Introduction Freezing of gait (FOG) is a debilitating symptom that significantly impacts individuals with Parkinson's disease (PD). In China, approximately 30% of PD patients experience FOG, with this prevalence increasing as the disease progresses (Gan et al. 2021).
Serum hepatitis B virus RNA in low-level viremia of chronic hepatitis B: clinical features and association with virological response - Virology Journal
The study cohort consisted of real-world outpatients who received ETV as initial treatment between February 2009 and September 2021 at Nanxishan Hospital of Guangxi Zhuang Autonomous Region (Guilin, China).
Multicilia dynamically transduce Sonic Hedgehog signaling to regulate choroid plexus functions
Keywords choroid plexus cilia Shh Smo Gαi cAMP Aqp1 Atp1a2 FoxJ1 cerebrospinal fluid CSF Research topic(s) CP: Cell biology Introduction The choroid plexus is a highly vascularized secretory neuroepithelium in brain ventricles, regulating dynamic cerebrospinal fluid (CSF) production to support neuronal development and homeostasis.1,2,3 The choroid plexus consists of a multiciliated epithelial monolayer that envelops the underlying capillaries and connective tissue.1,2 Through the choroid...
Prescribed‐Time Event‐Triggered Distributed Optimization With Privacy Protection Over Directed Networks
Conflicts of Interest The authors declare no conflicts of interest. References 1 and , “Initialization-Free Distributed Coordination for Economic Dispatch Under Varying Loads and Generator Commitment,” Automatica 74 (2016): 183–193. 2, “Distributed Gradient Methods for Convex Machine Learning Problems in Networks: Distributed Optimization,” IEEE Signal Processing Magazine 37, no. 3 (2020): 92–101.
An orange peel-derived zirconium-coordination polymer for highly efficient reductive upgrading of 5-hydroxymethylfurfural
An orange peel-derived zirconium-coordination polymer for highly efficient reductive upgrading of 5-hydroxymethylfurfural Both the use of renewable natural sources to prepare catalytic materials and the Meerwein-Ponndorf-Verley (MPV) reduction for carbonyl compounds are very attractive topics in catalysis. Neohesperidin (NES) with rich oxygen-containing groups can bind to various metal ions.
Research on Optimization of Sulfur Solubility Testing Method for High-Sulfur Natural Gas
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Enhanced Degradation of Deltamethrin in Water through Ferrous Ion Activated Sulfite: Efficiency and Mechanistic Insights
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Sub-Second Electrochemiluminescence Imaging Assay of SARS-CoV-2 Nucleocapsid Protein Based on Reticulation of Endo-Coreactants
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
Soliton and bound-state soliton mode-locked fiber laser based on polarization-dependent grating
We demonstrate the generation of solitons and bound-state solitons in a passively mode-locked fiber laser based on the nonlinear polarization rotation effect by polarization-dependent helical grating. The CO2-laser-inscribed grating has a high polarization-dependent loss of 24.4 dB at 1558.4 nm, which has facilitated the achievement of stable mode locking. The soliton laser could generate 548.9 fs pulses at 1560.59 nm with a spectrum bandwidth of 5.45 nm and a signal-to-noise ratio of 75.2 dB.
Amplification of an Electrochemiluminescence-Emissive Aptamer into DNA Nanotags for Sensitive Fecal Calprotectin Determination
The precision additive manufacturing and tessellated multitasking out of the structural DNA nanotechnology enable a configurable expression of densified electrochemiluminescent (ECL) complexes, which would streamline the bioconjugation while multiplying signals. Herein, a completely DNA-scaffold ECL “polyploid” was replicated out via the living course of rolling circle amplification.
All-Fiber Narrow-Bandwidth Mode-Locked Laser Based on Polarization-Dependent Helical Long-Period Grating
Open AccessArticle by Ying Wan 1,*, Chen Jiang 2, Zuxing Zhang 2, Yaya Mao 1, Jianxin Ren 1, Jianxiang Wen 3 and Yunqi Liu 3 1 The Jiangsu Key Laboratory for Optoelectronic Detection of Atmosphere and Ocean, School of Physics and Optoelectronic Engineering, Nanjing University of Information Science & Technology, 219 Ningliu Road, Nanjing 210044, China 2 Advanced Photonic Technology Lab, College of Electronic and Optical Engineering & College of Flexible Electronics (Future Technology),...
Removal of Membrane Fouling and Control of Halogenated By-Products by a Combined Cleaning Process with Peroxides and Sodium Hypochlorite
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Controllable Mitochondrial Aggregation and Fusion by a Programmable DNA Binder
Controllable Mitochondrial Aggregation and Fusion by a Programmable DNA Binder Longyi Zhu, Yiting Shen, Shengyuan Deng, Ying Wan, Jun Luo, Yan Su, Mingxu You, Chunhai Fan and Kewei Ren Abstract DNA nanodevices have been feasibly applied for various chemo-biological applications, but their functions as precise regulators of intracellular organelles are still limited. Here, we report a synthetic DNA binder that can artificially induce mitochondrial aggregation and fusion in living cells.
Multiple core modes conversion using helical long-period fiber gratings
Abstract We propose and demonstrate the fabrication of an all-fiber mode converter enabling simultaneous generation of multiple high-order core modes, which is realized by inscribing a helical long-period grating (HLPG) in a few-mode fiber (FMF) using a femtosecond laser. Helical refractive index modulation is introduced by continuously irradiating the core region with a highly focused femtosecond laser, while the fiber moves in a spiral path through a three-dimensional translation stage.
Joint Optimization of Data Transmission and Energy Harvesting in Relay Satellite Networks
Abstract : Satellite network is considered a prominent architecture for future space-air-ground integrated networks, where the relay satellite network (RSN) plays an essential role in data transmission. However, the relay satellite network faces practical challenges. First, due to the dynamic network topology and limited resources such as storage capacity, antennas, and bandwidth, optimizing data transmission and resource allocation in a resource-constrained stochastic system is challenging.
Manufacture of Bilayered Composite Hydrogels with Strong, Elastic, and Tough Properties for Osteochondral Repair Applications
1. Introduction Articular cartilage is a tissue with avascular features, and it has the limited ability to regenerate once damaged, especially for cartilage damage with a large defect size [1]. The cartilage damages often induce osteochondral defects (OCDs), and in addition, some subchondral bone-associated diseases, such as osteochondritis dissecans, osteonecrosis, and osteochondral fracture, can also cause OCDs [1,2].
A Brief Survey of Recent Advances and Methodologies for the Security Control of Complex Cyber–Physical Networks
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Ying Wan 1 and Jinde Cao 1,2,* 1 Department of Systems Science, School of Mathematics, Southeast University, Nanjing 210096, China 2 Yonsei Frontier Lab, Yonsei University, Seoul 03722, Republic of Korea * Author to whom correspondence should be addressed.
Palladium catalyzed radical relay for the oxidative cross-coupling of quinolines - Nature Communications
Abstract Traditional approaches for transition-metal catalyzed oxidative cross-coupling reactions rely on sp2-hybridized starting materials, such as aryl halides, and more specifically, homogeneous catalysts. We report a heterogeneous Pd-catalyzed radical relay method for the conversion of a heteroarene C(sp3)–H bond into ethers.
Breaking scaling relationships in alkynol semi-hydrogenation by manipulating interstitial atoms in Pd with d-electron gain - Nature Communications
Abstract Pd catalysts are widely used in alkynol semi-hydrogenation. However, due to the existence of scaling relationships of adsorption energies between the key adsorbed species, the increase in conversion is frequently accompanied by side reactions, thereby reducing the selectivity to alkenols. We report that the simultaneous increase in alkenol selectivity and alkynol conversion is achieved by manipulating interstitial atoms including B, P, C, S and N in Pd catalysts.
Thermal Activation of Peracetic Acid in Aquatic Solution: The Mechanism and Application to Degrade Sulfamethoxazole
Chemical oxidation using peracetic acid (PAA) can be enhanced by activation with the formation of reactive species such as organic radicals (R–O•) and HO•. Thermal activation is an alternative way for PAA activation, which was first applied to degrade micropollutants in this study. PAA is easily decomposed by heat via both radical and nonradical pathways.
Development of Stabilizing Formulations of a Trivalent Inactivated Poliovirus Vaccine in a Dried State for Delivery in the NanopatchTM Microprojection Array
Publication HistoryPublished online: February 05, 2018Accepted: January 26, 2018; Received in revised form: January 22, 2018; Received: October 20, 2017;
Primary cardiac diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression in an immunocompetent Chinese elderly woman
Publication HistoryPublished online: August 04, 2017Accepted: July 27, 2017; Received in revised form: July 26, 2017; Received: June 14, 2017;
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