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CoRegNet: Unraveling Gene Co-Regulation Networks from Public RNA-Seq Repositories Using a Beta-Binomial Statistical Model
Keywords Humans, RNA-Seq, Gene Regulatory Networks, Models, Statistical, Sequence Analysis, RNA, Gene Expression Profiling, gene network, co-regulation network, beta-binomial statistical model, non-linear correlation, Simpson’s paradox Abstract Millions of RNA sequencing samples have been deposited into public databases, providing a rich resource for biological research. These datasets encompass tens of thousands of experiments and offer comprehensive insights into human cellular regulation.
CoRegNet: Unraveling Gene Co-regulation Networks from Public RNA-Seq Repositories Using a Beta-Binomial Statistical Model
Abstract Millions of RNA sequencing samples have been deposited into public databases, providing a rich resource for biological research. These datasets encompass tens of thousands of experiments and offer comprehensive insights into human cellular regulation. However, a major challenge is how to integrate these experiments that acquired at different conditions.
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