Ying Yi
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Regulation of Extracellular HMGB-1 Alarmin Levels by CIGB-300 Anticancer Peptide In Vitro e In Vivo
You are already at the latest version HMGB-1 is an alarmin representative of DAMP playing a central role in the immuno-genic cell death (ICD), a necessary condition in the dialogue stablished between dying tumor cells and immune system during some anticancer therapies. Therefore, early screening for ICD inducers represents a major priority in drug development today.
NAT10 as a central node in cancer biology: integrating epitranscriptomic regulation, metabolic reprogramming, and immune modulation
Abstract N-acetyltransferase 10 (NAT10), the sole known mRNA N4-acetylcytidine (ac4C) writer, has emerged as a central regulator of cancer adaptation. Beyond its canonical role in RNA acetylation, NAT10 integrates environmental stress signals—including hypoxia, metabolic imbalance, and inflammatory cues—with epitranscriptomic remodeling to sustain malignant progression.
Association between the uric acid to high-density lipoprotein cholesterol ratio and estimated glomerular filtration rate decline in community-managed patients with type 2 diabetes: a retrospective cohort study
Abstract Background: The uric acid to high-density lipoprotein cholesterol ratio (UHR), a composite biomarker integrating pro-inflammatory stress and vascular protection loss, has been linked to diabetic kidney disease (DKD) in cross-sectional studies, but longitudinal evidence on its association with continuous eGFR decline remains limited.
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