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Ying-Ying Wang on Muck Rack

Ying-Ying Wang

As seen in: Nature, Wiley Online Library, BMJ Open, MDPI, Science Magazine, Royal Society of Chemistry, Cell Press, Physical Review B, Dove Medical Press, Diabetes Care Magazine and
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Articles

Molecular glue that stabilizes the LRPPRC− MET -G4 interaction complex to drive MET downregulation

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By Ying Zheng, Li-Fang Zhang, Xin-Yuan Chen, Si-Han He, Juan-Nan Chen, Yu Wang, Ying-Ying Wang, Li Tang, Ke-wei Zheng, Hao Zhang, Kai-Bo Wang, Ling-Yi Kong, Yi-Pu Li, Yu-Shuang Liu, Rong-Shuang Cheng, Sheng-Tao Xu, Jin-Lei Bian
| Nature Verified
Abstract Targeting the MET oncoprotein is an effective strategy in precision cancer therapy, whereas its clinical efficacy varies dramatically across tumor types. Herein, we explore an alternative approach to downregulate MET at the transcriptional level. We identify a cis-regulatory element in the MET proximal promoter that forms a stable parallel G-quadruplex (MET-G4).
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Hippocampal Satb2 regulates the cognitive function of adult mice through pleiotrophin

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By Yu-Bing Wang, Ying-Ying Wang, Yuan-Yuan Yong, Yan-yan Wang, Ting-Ting Zhang, Tao Chang, Hui-Xiang Yang, Ning-Ning Song, Yu-Qiang Ding, Xuan Zhao, Lei Zhang, Xin-Ren Yu, Zhi-Yi Tu, Qiu-Xiang Chen, Pin-Xi Xie, Jia-Jun Sun
| Nature Verified
Abstract The special AT-rich sequence-binding protein 2 (SATB2) is associated with human cognitive ability. Mutations in the SATB2 gene lead to SATB2-associated syndrome (SAS), characterized by severe intellectual disability. SATB2 is mainly expressed in pyramidal neurons in the cerebral cortex and hippocampus, playing a crucial role in cognitive processes. However, the function of SATB2 in the adult hippocampus remains unclear.
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Dynamics and heterogeneity of the neurovascular unit in ischemic stroke

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By Peng Teng, Ying-Ying Wang, Rui Nie, Ning Liu, Shu-Guang Yang, Feng-Quan Zhou, Chen-Yun Ding, Jia-Jie Huang, Yu-Cai Hong
| Cell Press Verified
Keywords ischemic stroke neurovascular unit cellular architecture metabolic homeostasis heterogeneity Targeting the neurovascular unit: a critical multicellular system affected by ischemic stroke Ischemic stroke (IS) (see Glossary) remains a major global health burden, associated with high mortality and significant long-term neural functional disability [1,2].
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