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Venetoclax combined with intensive chemotherapy as induction chemotherapy in newly diagnosed AML with FLT3-ITD-mutation
Dear Editor The FMS-internal tandem duplication (FLT3-ITD) is found in approximately 20–25% of de novo AML. Improvements in overall survival (OS) have been achieved with the development of FLT3 inhibitors (midostaurin, quizartinib, and gilteritinib) and allogeneic hematopoietic stem-cell transplantation (allo-HSCT) [1,2,3]. Consequently, the 2022 European Leukemia Network (ELN) guidelines reclassified FLT3-ITD-mutated AML as intermediate risk disease.
Gene- and subtype-dependent prognostic impact of ras pathway mutations in acute myeloid leukemia: a cohort study of 2,500 patients
To the Editor: Acute myeloid leukemia (AML) is a hematologic malignancy driven by diverse molecular aberrations [1, 2]. Constitutive activation of signal transduction pathways is a hallmark of leukemogenesis [1, 3]. Among these, the RAS/MAPK signaling pathway is a central regulator of critical cellular processes, including proliferation, differentiation, and apoptosis [4].
CBFB::MYH11 MRD after the second chemotherapy cycle: a guide for allogeneic transplantation in favorable-risk AML
Abstract Although acute myeloid leukemia (AML) with CBFB::MYH11 rearrangement is classified as favorable-risk, approximately 40% of patients experience relapse. We evaluated the prognostic impact of CBFB::MYH11 transcript levels and the optimal timing of allogeneic hematopoietic cell transplantation (allo-HCT) at first complete remission (CR1). A total of 186 patients with CBFB::MYH11-rearranged AML treated with intensive induction chemotherapy were included.
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