Yingchun Hu

Abstract This study aimed to screen lysosome-related genes that distinguish sepsis from Systemic Inflammatory Response Syndrome (SIRS), in order to provide potential targets for the differential diagnosis of sepsis and for lysosome-targeted therapeutic strategies. Peripheral blood samples were collected from 12 SIRS patients and 20 sepsis patients for RNA sequencing and differential expression analysis. Meanwhile, lysosome-related gene sets were obtained from the Gene Ontology database.

Abstract Desmosomes are cell-cell adhesive junctions that provide structural integrity and mechanical resistance to tissues. Disruptions in desmosome organization lead to severe cardiac and dermatological disorders. Emerging evidence reveals that desmosomes exhibit dynamic behaviors during remodeling. However, the mechanisms that initiate and regulate these dynamics under physiological conditions, and their correlation with desmosome-related disorders remain elusive.

Abstract Autophagy is a fundamental process for maintaining cell homeostasis, and STX17-mediated autophagosome–lysosome fusion is essential for cargo degradation and recycling. The translocation of STX17 to the autophagosome membrane is necessary for the fusion, yet the mechanism governing this process remains to be fully elucidated.