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Yingchun Luo

As seen in: Nature, Wiley Online Library, EBioMedicine
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Articles

SIRT1 deficiency promotes age-related heart failure through enhancing ferroptosis via GATA4-HADHA-GPX4 axis

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By Yu Duan, Yingchun Luo, Xuejie Han, Hui Yu, Hanwen Liu, Yun Zhou, Yunlong Gao, qian Xu, Ying Wei, Yong Seok Hong, Haibo Jia, YUE LI, Yun Zhang, Ruoxin Min, Xuanrui Ji
| Nature Verified
Abstract Aging is a major contributor to the escalating prevalence of heart failure (HF). Ferroptosis has been implicated in age-related disorders and cardiovascular diseases. The role of ferroptosis in age-related HF remains unclear. Here, we show that aged rats exhibit impaired cardiac function accompanied by hallmark features of ferroptosis, including reduced glutathione peroxidase 4 (GPX4) expression and excessive lipid peroxidation.
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Echocardiographic findings and pregnancy outcomes for fetuses with complete closure of the ductus arteriosus

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By Lixia Liu, Ying Deng, Yanling Liang, Yingchun Luo
| Wiley Online Library Verified
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available from the corresponding author upon reasonable request.
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Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis

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By Yingchun Luo, Yun Zhang, Xuejie Han, Yue Yuan
| EBioMedicine Verified
Keywords Cold Atrial fibrillation Gut microbiota Akkermansia muciniphila TMAO Abbreviations AF (Atrial fibrillation) CF (Cardiac fibroblasts) CM (Cardiac myocytes) FMT (Fecal microbiota transplantation) NMDs (Non-metric multidimensional scaling) RT (Room temperature) SR (Sinus rhythm) TMAO (Trimethylamine N-oxide) Evidence before this study Mounting studies have linked cold exposure to the higher risk of AF and poor prognosis of AF patients.
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