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Yingcong Li

As seen in: Nature, MDPI, Science Magazine, BioRxiv
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Articles

Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity - Nature Structural & Molecular Biology

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By Youngseo Cheon, Erik Alvstad, Denis Torre, Daniel Quach, Jennifer Nguyen, Kwangbeom Hyun, Mingqi Zhou, Tianxiong Yu, Liang Liu, Yoseop Yoon, Fairlie Reese, Yingcong Li, Frederick J. Arnold, Yesai Fstkchyan, Uttiya Basu, Evgeny Kvon, Enza Maria Valente, Minji Byun, Ernesto Guccione, Yongsheng Shi, Zhiping Weng, Marcus M. Seldin, Ivan Marazzi, Lauren Faraone
| Nature Verified
Abstract Transposable elements (TEs) in the human genome are the heritage of ancient parasitic infections. While most of human DNA comprises TEs and TE-derived elements, their repetitive nature poses technical challenges; thus, little is known about their positional identity and regulatory roles. Here, by integrating long-read and multidimensional transcriptional analyses, we investigate when, where and how TEs become part of a gene.
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Crohn’s Disease-associated variant in laccase domain containing 1 (LACC1) modulates T cell gene expression, metabolism and T cell function - Nature Communications

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By Yingcong Li, Gabriel Ascui, Thomas Riffelmacher, Vivek Chandra, Benjamin J. Schmiedel, Pandurangan Vijayanand
| Nature Verified
Abstract Genome wide association studies (GWAS) identify many risks for Crohn’s disease (CD), including a site near the metabolism gene laccase domain containing 1 (LACC1). We previously found this site near LACC1 was associated with decreased LACC1 expression in T lymphocytes, yet the mechanism affecting gene expression and its links to T cell function and inflammatory disease were unknown. Here we identify variants in the promoter region that influence transcription of LACC1.
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NSGA-III-Based Production Scheduling Optimization Algorithm for Pressure Sensor Calibration Workshop

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By Ying Zou, Zuguo Chen, Yingcong Li, Shangyang Zhu
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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