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ArticleVolume 86, Issue 14p2811-2827.e10Open access Affiliations & Notes 1Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, 92093, United States of America 2Sanford Stem Cell Institution Innovation Center, Stem Cell Program, University of California, San Diego, La Jolla, CA, 92037, United States of America 3Institute for Genomic Medicine, University of California, San Diego, La Jolla, CA, 92093, United States of America 4Bioinformatics and...
Keywords RNA nuclear retention intron retention RNA export RNA degradation splicing RNA polyadenylation Introduction In eukaryotic cells, the separation of mRNA biogenesis and translation into distinct compartments requires exquisite quality control. A key aspect of this surveillance is the selective export of properly processed RNAs from the nucleus.
Abstract Transposable elements (TEs) in the human genome are the heritage of ancient parasitic infections. While most of human DNA comprises TEs and TE-derived elements, their repetitive nature poses technical challenges; thus, little is known about their positional identity and regulatory roles. Here, by integrating long-read and multidimensional transcriptional analyses, we investigate when, where and how TEs become part of a gene.
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