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Zhiping Weng on Muck Rack

Zhiping Weng

As seen in: Nature, Genome Biology, BioRxiv, Cell Press
Professor and Chair, Department of #Genomics and #ComputationalBiology @UMassGCB, UMass Chan Medical School @UMassChan, Li Weibo Chair in Biomedical Research
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Articles

Transposable element–gene chimera cartography, origination and role in enhancing transcriptome plasticity - Nature Structural & Molecular Biology

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By Youngseo Cheon, Erik Alvstad, Denis Torre, Daniel Quach, Jennifer Nguyen, Kwangbeom Hyun, Mingqi Zhou, Tianxiong Yu, Liang Liu, Yoseop Yoon, Fairlie Reese, Yingcong Li, Frederick J. Arnold, Yesai Fstkchyan, Uttiya Basu, Evgeny Kvon, Enza Maria Valente, Minji Byun, Ernesto Guccione, Yongsheng Shi, Zhiping Weng, Marcus M. Seldin, Ivan Marazzi, Lauren Faraone
| Nature Verified
Abstract Transposable elements (TEs) in the human genome are the heritage of ancient parasitic infections. While most of human DNA comprises TEs and TE-derived elements, their repetitive nature poses technical challenges; thus, little is known about their positional identity and regulatory roles. Here, by integrating long-read and multidimensional transcriptional analyses, we investigate when, where and how TEs become part of a gene.
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Single-cell transcriptomic and genomic changes in the ageing human brain - Nature

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By Tianxiong Yu, Christina E Baer, Yerin Kim Verified, Zhiping Weng
| Nature Verified
Abstract Over time, cells in the brain and in the body accumulate damage, which contributes to the ageing process1. In the human brain, the prefrontal cortex undergoes age-related changes that can affect cognitive functioning later in life2. Here, using single-nucleus RNA sequencing (snRNA-seq), single-cell whole-genome sequencing (scWGS) and spatial transcriptomics, we identify gene-expression and genomic changes in the human prefrontal cortex across lifespan, from infancy to centenarian.
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A novel NLP-based method and algorithm to discover RNA-binding protein (RBP) motifs, contexts, binding preferences, and interactions

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By Zhiping Weng, Shaimae I Elhajjajy
| BioRxiv
Abstract RNA-binding proteins (RBPs) are essential modulators in the regulation of mRNA processing. The binding patterns, interactions, and functions of most RBPs are not well-characterized. Previous studies have shown that motif context is an important contributor to RBP binding specificity, but its precise role remains unclear.
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