Yingming Zhao
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BRD2 is a transcriptional coactivator of Smad3 in mediating TGF-β tumor suppressive responses
Abstract Transforming growth factor-β (TGF-β) is a multifunctional cytokine that regulates cell proliferation, differentiation, migration, and apoptosis. It is generally accepted that TGF-β induces cellular responses through Smad-dependent gene transcription. However, the underlying mechanisms that modulate the transcriptional activities of Smads are not yet fully understood.
Frontiers | Cardiac structure and inflammation drive memory impairment via dual pathways of heart-brain axis dysregulation in atrial fibrillation patients undergoing catheter ablation
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1 Introduction AF—the most prevalent sustained cardiac arrhythmia worldwide (Nielsen et al., 2022)—imposes burdens extending beyond cardiovascular complications: accumulating clinical evidence reveals that 22–51% of patients with AF experience persistent memory impairment (Knecht et al., 2008; Salvadori et al., 2023; Wang et al., 2021).
By Xin Chen, Jie Ni, Yu Wang, Dandan Kou, Xunwen Xue, Yingming Zhao, Biao Xu, Ming Li, Jiu Chen, Danni Ge
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Frontiers
Arsenic regulates ALKBH1 abundance and substrate specificity to promote translation and tumorigenicity
Keywords arsenic m6A mRNA methylation skin cancer translation Research topic(s) CP: Cancer Introduction Arsenic is a metalloid found both within the Earth’s crust and derived from anthropogenic sources, such as industry waste discharge.1 Arsenic from the Earth’s crust can leach into neighboring bodies of water and lead to contamination.1 A primary source of arsenic exposure is through ingesting contaminated drinking water.
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